柴胡皂苷元A
| 中文名称 | 柴胡皂苷元A |
|---|---|
| 中文同义词 | 柴胡皂苷元A 标准品;柴胡皂苷元A,10 MM DMSO 溶液;(3S,4R,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇 |
| 英文名称 | saikogenin A |
| 英文同义词 | Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-;Clinopodiside A1;Saikogenin A,inhibit,Inhibitor,DPP,1166100,Dipeptidyl Peptidase;Saikogenin A, 10 mM in DMSO;(3S,4R,6aR,6bS,8S,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol |
| CAS号 | 5092-09-1 |
| 分子式 | C30H48O4 |
| 分子量 | 472.7 |
| EINECS号 | |
| 相关类别 | 对照品;中药对照品;标准品-对照品;新品;对照品;标准品，对照品 |
| Mol文件 | 5092-09-1.mol |
| 结构式 |  |
柴胡皂苷元A 性质
| 熔点 | 287-293 °C |
|---|---|
| 沸点 | 607.4±55.0 °C(Predicted) |
| 密度 | 1.16±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.47±0.70(Predicted) |
| 颜色 | 白色至米白色 |
Saikogenin A 可从中药柴胡中提取，是一种二肽基肽酶 IV (DPP-IV) 抑制剂。
DPP-IV
Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.
Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.