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| | N,N-dimethylarginine Basic information |
| Product Name: | N,N-dimethylarginine | | Synonyms: | N,N-dimethylarginine;(S)-2-Amino-5-(3,3-dimethylguanidino)pentanoic acid;N(omega),N(omega)-dimethyl-L-arginine;N5-[(Dimethylamino)iminomethyl]-L-ornithine, 97%;N,N-dimethylarginine, 2-amino-5-(3,3-dimethylguanidino)pentanoic acid L-Arg(Me, Me)-OH (asymmetrical);Asymmetric dimethylarginine;Arginine Impurity 12（N, N-Dimethyl-L-Arginine）;L-Arg(Me,Me)-OH(asymmetrical), >97% | | CAS: | 30315-93-6 | | MF: | C8H18N4O2 | | MW: | 202.25 | | EINECS: | | | Product Categories: | | | Mol File: | 30315-93-6.mol |  |
| | N,N-dimethylarginine Chemical Properties |
| Boiling point | 340.8±52.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMF: 5 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): freely soluble | | form | A crystalline solid | | pka | 2.50±0.24(Predicted) |
| | N,N-dimethylarginine Usage And Synthesis |
| Uses | Metabolomics | | Definition | ChEBI: A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group. | | General Description | Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. Asymmetric dimethylarginine is created in protein methylation, a common mechanism of post-translational protein modification. This reaction is catalyzed by an enzyme set called S-adenosylmethionine protein N-methyltransferases (protein methylases I and II). The methyl groups transferred to create ADMA are derived from the methyl group donor S-adenosylmethionine, an intermediate in the metabolism of homocysteine. (Homocysteine is an important blood chemical, because it is also a marker of cardiovascular disease). After synthesis, ADMA migrates into the extracellular space and then into blood plasma. |
| | N,N-dimethylarginine Preparation Products And Raw materials |
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