2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether manufacturers
- HBDDE
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- $178.00 / 1mg
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2026-01-09
- CAS:154675-18-0
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
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| | 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Basic information |
| Product Name: | 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether | | Synonyms: | Hhbpdde;[1,1'-Biphenyl]-2,2',3,3',4,4'-hexol, 6,6'-bis(methoxymethyl)-;HBDDE, PKCalpha and PKCgamma inhibitor | | CAS: | 154675-18-0 | | MF: | C16H18O8 | | MW: | 338.31 | | EINECS: | | | Product Categories: | | | Mol File: | 154675-18-0.mol |  |
| | 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Chemical Properties |
| Melting point | 165-168℃ | | storage temp. | -20°C | | solubility | ethanol: 1mg/mL
warm water: 1mg/mL
DMSO: 5mg/mL | | form | Orange solid. | | color | Brown to khaki | | Sensitive | Light Sensitive | | InChI | 1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3 | | InChIKey | NEBCAMAQXZIVRE-UHFFFAOYSA-N | | SMILES | O(Cc1c(c(c(c(c1)O)O)O)c2c(c(c(cc2COC)O)O)O)C |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Usage And Synthesis |
| Uses | HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2]. | | Definition | ChEBI: 5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol is a tannin. | | Biological Activity | Cell permeable: yes', 'Primary Target
PKCα', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 43 μM against PKCα | | IC 50 | PKCα: 43 μM (IC50); PKCγ: 50 μM (IC50) | | References | [1] A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. DOI:10.1016/s0006-2952(00)00398-1
[2] Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200. DOI:10.1021/jm00027a025 |
| | 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Preparation Products And Raw materials |
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