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pyrrolosporin A

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pyrrolosporin A Basic information
Product Name:pyrrolosporin A
Synonyms:pyrrolosporin A
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MW:0
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pyrrolosporin A Structure
pyrrolosporin A Chemical Properties
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pyrrolosporin A Usage And Synthesis
Chemical PropertiesPyrrolosporin A is isolated as a white crystalline solid having a MW of 879 and MF of C44H54Cl2N2O10. Pyrrolosporin A has the unique feature of 1 3-membered macrolide in which a spiro-a-acyltetronic acid moiety constitutes the lactone group. Pyrrolosporin A exhibits in vivo antitumor activity against P388 leukemia. Pyrrolosporin A also shows activity against Gram-positive. The structure of pyrrolosporin A. SEPT. 1996 bacteria is weakly active against Gram-negative bacteria[1].
DefinitionPyrrolosporin A is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed-phase HPLC (C18).
References [1] K S Lam. “Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. I. Taxonomy of producing organism, fermentation and biological activity.” Journal of Antibiotics 49 9 (1996): 860–4.
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