隐陡头菌素M
中文名称 | 隐陡头菌素M |
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中文同义词 | 隐陡头菌素M |
英文名称 | illudin M |
英文同义词 | illudin M;(3S)-2,3-Dihydro-3α,6β-dihydroxy-2,2,4,6-tetramethylspiro[5H-indene-5,1'-cyclopropan]-7(6H)-one;(3'S,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one;Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-, (3'S,6'R)-;(3'S,6'R)-3',6'-dihydroxy-2',2',4',6'-tetramethyl-2',3',6',7'-tetrahydrospiro[cyclopropane-1,5'-inden]-7'-one |
CAS号 | 1146-04-9 |
分子式 | C15H20O3 |
分子量 | 248.32 |
EINECS号 | |
相关类别 | ADC |
Mol文件 | 1146-04-9.mol |
结构式 |
隐陡头菌素M 性质
熔点 | 120-122.5° (Matsumoto); mp 128-130° (McMorris) |
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沸点 | 452.4±45.0 °C(Predicted) |
密度 | 1.24±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMF:可溶; DMSO:可溶;乙醇:可溶;甲醇:可溶 |
形态 | 固体 |
酸度系数(pKa) | 12.57±0.70(Predicted) |
颜色 | 米白色至浅黄色 |
Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。
Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.
Apoptosis Analysis
Cell Line: | Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) |
Concentration: | 0.01 μM, 1 μM, 10 μM |
Incubation Time: | 24 hours, 48 hours,72 hours, 96 hours, 120 hours |
Result: | Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%). |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-122493 | 隐陡头菌素M Illudin M | 1146-04-9 | 1mg | 4000元 |
2024/08/19 | HY-122493 | 隐陡头菌素M Illudin M | 5 mg | 8400元 |