| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:NLRP3-IN-17
CAS:2254432-75-0
Purity:95% Package:2mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:NLRP3-IN-17
CAS:2254432-75-0
Package:2mg/RMB 990
|
NLRP3-IN-17 manufacturers
- NLRP3-IN-17
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- $140.00 / 2mg
-
2025-04-28
- CAS:2254432-75-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | NLRP3-IN-17 Basic information |
| Product Name: | NLRP3-IN-17 | | Synonyms: | NLRP3-IN-17;Benzenesulfonimidamide, N-cyano-N′-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-methyl- | | CAS: | 2254432-75-0 | | MF: | C21H22N4O2S | | MW: | 394.49 | | EINECS: | | | Product Categories: | | | Mol File: | 2254432-75-0.mol |  |
| | NLRP3-IN-17 Chemical Properties |
| density | 1.376±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | color | White to off-white |
| | NLRP3-IN-17 Usage And Synthesis |
| Uses | NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research[1]. | | in vivo | NLRP3-IN-17 (compound 15) (3 mg/kg; po) displays desired PK profile, the AUC, t and F% values are 4.2 μg.h/mL, 2.91 h, and 56%, respectively[1].
NLRP3-IN-17 (10 mg/kg; po; single dosage) significantly inhibit NLRP3 dependent IL-1β secretion in acute in vivo LPS+ATP
challenged model in female C57BL/6 mice, it decreases the IL-1β levels by 44%[1]. | | IC 50 | NLRP3 inflammasome: 7 nM (IC50) | | References | [1] Sameer Agarwal, et al. Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2020 Feb 27;11(4):414-418. DOI:10.1021/acsmedchemlett.9b00433 |
| | NLRP3-IN-17 Preparation Products And Raw materials |
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