Pasiniazid manufacturers
- Pasiniazid USP/EP/BP
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- $1.10 / 1g
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2025-11-18
- CAS:2066-89-9
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Pasiniazid
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- $42.00 / 500mg
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2025-10-27
- CAS:2066-89-9
- Min. Order:
- Purity: 92.81%
- Supply Ability: 10g
- Pasiniazid
-
- $42.00 / 500mg
-
2025-10-27
- CAS:2066-89-9
- Min. Order:
- Purity: 92.81%
- Supply Ability: 10g
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| | Pasiniazid Basic information |
| Product Name: | Pasiniazid | | Synonyms: | isonicotinic acid hydrazide 4-aminosalicylate;ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT;PASINIAZID;isonicotinicacidhydrazidep-*aminosalicylate;PASINIAZIDISONIAZID AMINOSALICYLATE UV;Dipasic;Fintozid;Nidrapas | | CAS: | 2066-89-9 | | MF: | C13H14N4O4 | | MW: | 290.27 | | EINECS: | 218-183-2 | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 2066-89-9.mol |  |
| | Pasiniazid Chemical Properties |
| Melting point | 142-144° | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Water | | form | Solid | | color | Light yellow to khaki | | InChI | InChI=1S/C7H7NO3.C6H7N3O/c8-4-1-2-5(7(10)11)6(9)3-4;7-9-6(10)5-1-3-8-4-2-5/h1-3,9H,8H2,(H,10,11);1-4H,7H2,(H,9,10) | | InChIKey | RKPHTRVPGYGVQD-UHFFFAOYSA-N | | SMILES | C1(C(=O)O)C=CC(N)=CC=1O.C1(C(=O)NN)=CC=NC=C1 |
| | Pasiniazid Usage And Synthesis |
| Originator | Pasinazid, Yick-Vic Chemicals | | Uses | antibacterial (tuberculostatic) | | Uses | Pasiniazid is an antituberculous agents against several species of rapidly growing mycobacteria (RGM). | | Manufacturing Process | 10 parts by weight of isonicotinoyl hydrazine was dissolved in 200 by volume of methanol by stirring at 60°C. Then 11.2 parts 4-aminosalycylic acid was added at 60°C. On cooling a salt of both compounds crystallized as yellow prisms with MP: 135°-140°C (decomposed).
Isonicotinic acid hydrazide compound with 4-aminosalicylic acid may be prepared from the same components by using 750 parts of water by volume as a solvent.
10 parts 4-aminosalicylic acid was dissolved in 600 volume parts of water containing 39 parts by volume 2 N ammonium hydroxide. 9 parts by weight isonicotinoyl hydrazide was added and the mixture was heated to 30°C. The solution was acidified with 49 parts by volume of 2 N acetic acid. On cooling isonicotinic acid hydrazide compound with 4-amino-salicylic acid crystallized, which decomposed at 135°-140°C.
The yield was almost quantitative | | Therapeutic Function | Antitubercular |
| | Pasiniazid Preparation Products And Raw materials |
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