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1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-

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1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:PARP1/2-IN-3
CAS:3032451-58-1
Package:50mg;10mg
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- Basic information
Product Name:1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-
Synonyms:1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-;PARP1/2-IN-3
CAS:3032451-58-1
MF:C26H21FN6O3
MW:484.48
EINECS:
Product Categories:
Mol File:3032451-58-1.mol
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- Structure
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- Chemical Properties
density 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.06±0.40(predicted)
Safety Information
MSDS Information
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- Usage And Synthesis
UsesPARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and <0.001 nM. PARP1/2-IN-3 inhibits the proliferation of Capan-1 wildtype, AZD2281 or BMN673 resistant cells with IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice[1].
IC 50PARP-1: 0.2235 nM (IC50)
References[1] Yang Chun, et al., Phthalazinone or quinazolinone derivatives, pharmaceutical compositions and uses thereof. CN118324766A
1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]- Preparation Products And Raw materials
Tag:1(2H)-Phthalazinone, 4-[[3-[[5,6-dihydro-3-(5-methyl-2-furanyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]carbonyl]-4-fluorophenyl]methyl]-(3032451-58-1) Related Product Information
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