|
| PANCREATIC POLYPEPTIDE (BOVINE) Basic information |
Product Name: | PANCREATIC POLYPEPTIDE (BOVINE) | Synonyms: | H-Ala-Pro-Leu-Glu-Pro-Glu-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Glu-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2;PANCREATIC POLYPEPTIDE (BOVINE);Pancreatic polypeptide (pig),6-L-glutamic acid- | CAS: | 179986-89-1 | MF: | | MW: | 0 | EINECS: | | Product Categories: | peptide | Mol File: | Mol File | |
| PANCREATIC POLYPEPTIDE (BOVINE) Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble in DMSO |
| PANCREATIC POLYPEPTIDE (BOVINE) Usage And Synthesis |
Biological Activity | Pancreatic Polypeptide, bovine is a linear polypeptide of 36 amino acids produced in the pancreas that inhibits pancreatic secretion induced by secretin and cholecystokinin. It is a neuropeptide (NPY) receptor agonist with high affinity for NPYR4. | in vitro | Pancreatic Polypeptide, bovine is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM. Pancreatic Polypeptide, bovine inhibits secretin- and cholecystokinin-stimulated pancreatic secretion. 125 I-Pancreatic Polypeptide, bovine shows no specific binding to pancreatic acini. | in vivo | Pancreatic Polypeptide (25 nmol/kg bw, ip) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice. Pancreatic Polypeptide, bovine (BPP; 40 μg/kg) inhibits CCK -33-induced pancreatic protein output during the entire bovine Pancreatic Polypeptide infusion period, but shows no effect on biliary protein output during CCK-33 or CCK-8 infusion. p> |
| PANCREATIC POLYPEPTIDE (BOVINE) Preparation Products And Raw materials |
|