N-Methyl-1-amino-hex-5-ene manufacturers
|
| | N-Methyl-1-amino-hex-5-ene Basic information |
| Product Name: | N-Methyl-1-amino-hex-5-ene | | Synonyms: | 5-HEXEN-1-AMINE, N-METHYL-;N-methylhex-5-en-1-amine;5-Hexen-1-aMine, N-Methyl-N-Methylhex-5-en-1-aMine;N-methyl-5-hexen-1-amine;N-Methyl-1-amino-hex-5-ene;N-Methylhex-5-en-1-amine,98% (stabilized with MEHQ) | | CAS: | 55863-02-0 | | MF: | C7H15N | | MW: | 113.2 | | EINECS: | | | Product Categories: | | | Mol File: | 55863-02-0.mol |  |
| | N-Methyl-1-amino-hex-5-ene Chemical Properties |
| Boiling point | 146.5±19.0 °C(Predicted) | | density | 0.764±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 10.74±0.10(Predicted) | | form | Oil | | color | Colourless | | Stability: | Volatile | | InChI | InChI=1S/C7H15N/c1-3-4-5-6-7-8-2/h3,8H,1,4-7H2,2H3 | | InChIKey | KKIMETYRXLWWSD-UHFFFAOYSA-N | | SMILES | C(NC)CCCC=C |
| | N-Methyl-1-amino-hex-5-ene Usage And Synthesis |
| Uses | N-Methylhex-5-en-1-amine can be used as a reagent to prepare quinazoline substituted cyclopentane and proline-urea based macrocycles as Hepatitis C virus (HCV) NS3/4A protease inhibitors. | | Synthesis | The following step: To a reaction flask was added a methanol solution containing 25% methylamine in an amount of 10 equivalents of methylamine. Subsequently 1 equivalent of 6-bromo-1-hexene was added to the reaction flask and mixed with stirring. The reaction mixture was heated to 40°C in an oil bath and kept at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to 20 °C and 0.1 equivalent of p-methoxyphenol was added as a stabilizer, along with 1 equivalent of sodium hydroxide. The excess methylamine methanol solution was recovered under negative pressure. Next, the mixture was heated to 50 °C and a colorless liquid product, N-methyl-5-hexen-1-amine, was obtained by distillation under reduced pressure. The yield of this step was 67% and the purity of the product was 96.5%. | | References | [1] Patent: CN108003037, 2018, A. Location in patent: Paragraph 0014-0028
[2] Bulletin de la Societe Chimique de France, 1975, p. 2315 - 2320 |
| | N-Methyl-1-amino-hex-5-ene Preparation Products And Raw materials |
|