|
|
| | TETRODOTOXIN CITRATE Basic information |
| Product Name: | TETRODOTOXIN CITRATE | | Synonyms: | TETRODOTOXIN;TETRODOTOXIN CITRATE;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE;citratodetetrodotoxina;tetrodotoxin,citrate(1:1)(salt);Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentolcitrat;Citrato de tetrodotoxina [spanish];Tetrodotoxin, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) (9ci) | | CAS: | 18660-81-6 | | MF: | C17H25N3O15 | | MW: | 511.39 | | EINECS: | 689-001-0 | | Product Categories: | Sodium channel | | Mol File: | 18660-81-6.mol |  |
| | TETRODOTOXIN CITRATE Chemical Properties |
| storage temp. | Desiccate at -20°C | | solubility | Citrate Buffer (pH 4.8): 30 mg/ml (100 mM) | | form | A solid | | pka | 8.76(at 25℃) | | Water Solubility | Soluble to 100 mM in water | | Stability: | Unstable in Acidic solution, Unstable In Acidic Solution |
| Hazard Codes | T+ | | Risk Statements | 26/27/28 | | Safety Statements | 22-36/37/39-45 | | RTECS | IO1450000 | | Toxicity | A toxin
contained in the ovary and liver of puffer fish, in the eggs of
the California newt and in some other animals. It is used as a
chemical tool for the study of ion channels. The s.c. LD50 in
mice is 10 mg/kg. It is a toxicant of nerve and muscle by
blocking sodium channels, this action causing nerve and muscle paralysis. Symptoms include weakening of voluntary muscles, respiratory failure from paralysis of the diaphragm and
hypotension. There is no antidote. Therapy involves artificial
respiration. |
| | TETRODOTOXIN CITRATE Usage And Synthesis |
| Description | TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Nav) channels, blocking nerve and muscle action potentials. It inhibits the Nav current in frog muscle and squid axon with IC50 values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a Kd value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Nav current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX , which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized. | | Uses | Tetrodotoxin Citrate is a highly selective, reversible sodium channel blocker. | | Biological Activity | Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin. | | storage | Store at -20°C |
| | TETRODOTOXIN CITRATE Preparation Products And Raw materials |
|