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Cefotaxime sodium

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Products Intro: Product Name:Cefotaxime sodium
CAS:64485-93-4
Purity:98% Package:1Kg;25kg/ Drum or as customer request
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Products Intro: Product Name:64485-93-4
CAS:64485-93-4
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Products Intro: Product Name:Cefotaxime Sodium
CAS:64485-93-4
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:Sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
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Products Intro: Product Name:Pharmaceutical Raw Material Cefotaxime Sodium Cas:64485-93-4
CAS:64485-93-4
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Products Intro: Product Name:cefotaxime sodium
CAS:64485-93-4
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Cefotaxime sodium manufacturers

  • Cefotaxime sodium
  • $2.70 / g/Bag
  • 2021-12-01
  • CAS:64485-93-4
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 10000kg
  • Cefotaxime sodium
  • $5396.80 / ASSAYS
  • 2021-11-02
  • CAS:64485-93-4
  • Min. Order: 10KG
  • Purity: 99%
  • Supply Ability: 1000kg
  • Cefotaxime sodium
  • $78.00-65.00 / KG
  • 2021-10-20
  • CAS:64485-93-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 9000kg/per week
Cefotaxime sodium Basic information
Brand Name(s) in US
Product Name:Cefotaxime sodium
Synonyms:Cefotaxime:Claforan;FIR-756;(6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;(6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;Cefotaxime sodium salt,Cefotaxim sodium salt;Cefotaxime Sodium (350 mg);Cefotaxime Sodium (250 mg)J0C189901ug/mg(ai);Cefotaxime Sodium (250 mg)
CAS:64485-93-4
MF:C16H16N5NaO7S2
MW:477.45
EINECS:264-915-9
Product Categories:CLAFORAN;antibiotic;API;Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Pharmaceutical intermediate;Biochemistry;Antibiotic Explorer;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharmaceutical
Mol File:64485-93-4.mol
Cefotaxime sodium Structure
Cefotaxime sodium Chemical Properties
Melting point 162-163 C
alpha D20 +55±2° (c = 0.8 in water)
refractive index 61 ° (C=1, H2O)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
form powder
color white to yellow
PHpH(100g/l, 25℃) : 4.5~6.5
Water Solubility Soluble in water.
Merck 14,1933
BRN 5711411
Stability:Stable. Incompatible with strong oxidizing agents.
Safety Information
Hazard Codes Xn,Xi
Risk Statements 42/43
Safety Statements 22-36/37-60-45-37-24
WGK Germany 2
RTECS XI0250000
HS Code 29419000
MSDS Information
ProviderLanguage
SigmaAldrich English
Cefotaxime sodium Usage And Synthesis
Brand Name(s) in USClaforan
Chemical PropertiesWhite to pale yellow crystalline powder
OriginatorClaforan,Hoechst-Roussel,W. Germany,1980
UsesBroad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group
UsesCephalosporin antibacterial
DefinitionChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.
Manufacturing ProcessA solution of 8 g of sodium bicarbonate in about 20 ml of ethanol was progressively added to 45.55 g of pure 3-acetoxymethyl-7-[2-(2-amino-4- thiazolyl)-2-methoxyiminoacetamido]-ceph-3-eme-4-carboxylic acid in 100 ml of distilled water and another 80 ml of ethanol and 4.5 g of activated carbon were added thereto. The mixture was stirred for 5 minutes and was filtered. The filter was rinsed with ethanol and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in 100 ml of ethanol and evaporated to dryness again. The residue was dissolved in 100 ml of methanol and the solution was poured into 2 l of acetone. The mixture was vigorously stirred and was vacuum filtered. The recovered product was rinsed with acetone and then ether and dried under reduced pressure to obtain 43.7 g of a white product which rehydrated in air to obtain a final weight of 45.2 g of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2- methoxyiminoacetamido]-ceph-3-eme-4-carboxylate.
Brand nameClaforan (Sanofi Aventis).
Therapeutic FunctionAntibiotic
Clinical UseCefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.
The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.
Veterinary Drugs and TreatmentsIn the United States, there are no cefotaxime products approved for veterinary species but it has been used clinically in several species when an injectable 3rd generation cephalosporin may be indicated.
Tag:Cefotaxime sodium(64485-93-4) Related Product Information
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