| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:(S)-AcenocouMarol
CAS:66556-78-3
Package:10Mg,1Mg
|
| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:(S)-AcenocouMarol;(S)-4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one; (-)-3-(α-Acetonyl-4-nitrobenzyl)-4-hydroxycouMarin; (-)-AcenocouMarin; (S)-(-)-AcenocouMarol; (S)-(-)-NicouMalone
CAS:66556-78-3
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
|
| Company Name: |
Cato Research Chemicals Inc.
|
| Tel: |
020-81960175 |
| Email: |
min.he@cato-chem.com |
| Products Intro: |
Product Name:(S)-AcenocouMarol
CAS:66556-78-3
Purity:95% Package:25Mg, 50Mg
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:(S)-Acenocoumarol
CAS:66556-78-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
Beijing Minruida Technology Co., Ltd.
|
| Tel: |
010-82387566 18001021521; |
| Email: |
sales@mreda.com.cn |
| Products Intro: |
Product Name:(S)-(-)-Nicoumalone
CAS:66556-78-3
Purity:95% Package:5mg
|
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| | (S)-(-)-Nicoumalone Basic information |
| | (S)-(-)-Nicoumalone Chemical Properties |
| Boiling point | 592.7±50.0 °C(Predicted) | | density | 1.427±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml; Ethanol: 0.2 mg/ml | | form | A crystalline solid | | pka | 4.50±1.00(Predicted) |
| | (S)-(-)-Nicoumalone Usage And Synthesis |
| Description | Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The S-enantiomer undergoes extensive first-pass metabolism during absorption from the gastrointestinal tract, whereas (R)-acenocoumarol is rapidly absorbed and provides essentially complete oral bioavailability. Perhaps related to these pharmacokinetic characteristics, (S)-acenocoumarol is less potent in vivo as an anti-coagulant than the (R)-enantiomer. As the clearance of acenocoumarol is ~20-fold faster than that for warfarin, the plasma concentrations of acenocoumarol are substantially lower than those for warfarin in patients receiving long-term treatment. | | Uses | S-Enantiomer of | | Definition | ChEBI: The (R)-enantiomer of acenocoumarol. |
| | (S)-(-)-Nicoumalone Preparation Products And Raw materials |
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