异隐丹参酮
| 中文名称 | 异隐丹参酮 |
|---|---|
| 中文同义词 | 异隐丹参酮;异丹参酮 III |
| 英文名称 | (8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione |
| 英文同义词 | (+)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione;(8S)-1,2,3,4,8,9-Hexahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione;Isotanshinone III;Phenanthro[3,2-b]furan-7,11-dione, 1,2,3,4,8,9-hexahydro-4,4,8-trimethyl-, (8S)-;Isocryptotanshinone;Isocryptotanshinon |
| CAS号 | 22550-15-8 |
| 分子式 | C19H20O3 |
| 分子量 | 296.36 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品 -中药标准品 |
| Mol文件 | 22550-15-8.mol |
| 结构式 |  |
异隐丹参酮 性质
| 熔点 | 121 °C |
|---|---|
| 沸点 | 470.807±45.00 °C(Press: 760.00 Torr)(predicted) |
| 密度 | 1.238±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
Isocryptotanshinone 是一种有效的信号传导与转录激活因子3 (STAT3) 和蛋白酪氨酸磷酸酶1 B (PTP1B) 的抑制剂，其对 PTP1B 的 IC50 值为 56.1 μM。
|
STAT3
|
PTP1B 56.1 μM (IC 50 ) |
It is showed that tanshinones significantly inhibited A549 proliferation and Isocryptotanshinone (ICTS) exhibits the strongest activity. Isocryptotanshinone inhibits the constitutive STAT3 and p-STAT3 (Y705) expression in concentration and time-dependent manners. Isocryptotanshinone dramatically inhibits the IL-6-stimulated expression of p-STAT3 (Y705) in a time-dependent manner.