4'-Hydroxyphenyl Carvedilol

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Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Carvedilol Impurity 12
CAS:142227-49-4
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
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Products Intro: Product Name:Carvedilol metabolite 4-Hydroxyphenyl Carvedilol；4-Hydroxyphenyl Carvedilol;4-Hydroxycarvedilol
CAS:142227-49-4
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences
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Products Intro: Product Name:4'-Hydroxyphenyl Carvedilol
CAS:142227-49-4
Purity:> 95% Remarks:Please reach out to us for more information about custom solutions.
Company Name: CR Corporation Limited
Tel: +8613062833949
Email: fred.wen@crcorporation.cn
Products Intro: Product Name:4'-Hydroxyphenyl carvedilol
CAS:142227-49-4
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
CAS:142227-49-4
Package:1mg;198USD

4'-Hydroxyphenyl Carvedilol manufacturers
4'-Hydroxyphenyl Carvedilol Basic information
Product Name:4'-Hydroxyphenyl Carvedilol
Synonyms:(R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL;(S)-(-)-4'-HYDROXYPHENYL-CARVEDILOL;(R)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol;(R)-4-Hydroxycarvedilol;(R)-BM 140686;(R)-BM 14686;(S)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol;(S)-4-Hydroxycarvedilol
CAS:142227-49-4
MF:C24H26N2O5
MW:422.47
EINECS:
Product Categories:Metabolite;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Heterocycles;Pharmaceuticals
Mol File:142227-49-4.mol
4'-Hydroxyphenyl Carvedilol Structure
4'-Hydroxyphenyl Carvedilol Chemical Properties
Melting point 163-165°C
Boiling point 702.0±60.0 °C(Predicted)
density 1.305±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.94±0.20(Predicted)
color White to Light Brown
InChI1S/C24H26N2O5/c1-29-23-13-16(27)9-10-21(23)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3
InChIKeyZCJHEORDHXCJNB-UHFFFAOYSA-N
SMILES[nH]1c2c(c4c1cccc4)c(ccc2)OCC(O)CNCCOc3c(cc(cc3)O)OC
Safety Information
WGK Germany WGK 3
HS Code 9999999999
Storage Class11 - Combustible Solids
Hazard ClassificationsAquatic Chronic 2
STOT RE 2
MSDS Information
4'-Hydroxyphenyl Carvedilol Usage And Synthesis
Description4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.
Chemical PropertiesOff-White Solid
UsesA metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.
Uses4'-Hydroxyphenyl Carvedilol is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.
UsesAn optically active metabolite of Carvedilol (C184625), a nonselective -adrenergic blocker with α1-blocking activity.
DefinitionChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles.
References[1] DAXESH P. PATEL. UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4′-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteers[J]. Biomedical Chromatography, 2013, 27 8: 974-986. DOI: 10.1002/bmc.2889
[2] H G OLDHAM  S E C. In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.[J]. Drug Metabolism and Disposition, 1997, 25 8: 970-977.
[3] THOMAS C MALIG. Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolites.[J]. MedChemComm, 2017: 606-615. DOI: 10.1039/c7md00014f
4'-Hydroxyphenyl Carvedilol Preparation Products And Raw materials
Tag:4'-Hydroxyphenyl Carvedilol(142227-49-4) Related Product Information
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