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| | 2-Fluoro-4-hydroxybenzaldehyde Basic information |
| | 2-Fluoro-4-hydroxybenzaldehyde Chemical Properties |
| Melting point | 168-170°C | | Boiling point | 254.2±20.0 °C(Predicted) | | density | 1.350±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | crystalline powder | | pka | 6.78±0.18(Predicted) | | color | Light tan | | InChI | InChI=1S/C7H5FO2/c8-7-3-6(10)2-1-5(7)4-9/h1-4,10H | | InChIKey | ONRPXRPUBXXCCM-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(O)C=C1F | | CAS DataBase Reference | 348-27-6(CAS DataBase Reference) |
| | 2-Fluoro-4-hydroxybenzaldehyde Usage And Synthesis |
| Uses | 2-Fluoro-4-hydroxybenzaldehyde is a useful reagent for preparation of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. | | Uses | 2-Fluoro-4-hydroxybenzaldehyde is mainly used as an intermediate for physiologically active compounds such as pharmaceuticals or pesticides and is a wide range of organic building blocks. Its structure contains fluorine, aldehyde groups, and phenolic hydroxyl groups, and these groups can add or replace other functional groups. | | Synthesis |
Preparation of 2-fluoro-4-hydroxybenzaldehyde involves: (1) mixing 3-fluorophenol (I), potassium carbonate, and 2-bromopropane in an organic solvent, and heating to react to obtain 1-fluoro-3-isopropoxybenzene (II); (2) dissolving compound (II) in an organic solvent and reacting with a brominating reagent to obtain 1-bromo-2-fluoro-4-isopropoxybenzene (III); (3) dissolving compound (III) in tetrahydrofuran, dripping isopropylmagnesium chloride/tetrahydrofuran solution at -10°C to 0°C, adding dimethylformamide to react after Grignard exchange to obtain 2-fluoro-4-isopropoxybenzaldehyde (IV); and (4) reacting compound (IV) with boron trichloride and deprotecting.
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| | 2-Fluoro-4-hydroxybenzaldehyde Preparation Products And Raw materials |
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