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| | Methyl tetrahydropyran-4-carboxylate Basic information |
| | Methyl tetrahydropyran-4-carboxylate Chemical Properties |
| Melting point | -33°C | | Boiling point | 197°C | | density | 1.080 g/mL at 20 °C(lit.) | | Fp | 86°C | | storage temp. | Sealed in dry,Room Temperature | | form | liquid | | color | Clear | | BRN | 114974 | | InChIKey | CNCMVGXVKBJYNU-UHFFFAOYSA-N | | CAS DataBase Reference | 110238-91-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36-36/37/38 | | Safety Statements | 26-37/39 | | RIDADR | 1993 | | WGK Germany | 2 | | Hazard Note | Harmful | | HS Code | 29329990 |
| | Methyl tetrahydropyran-4-carboxylate Usage And Synthesis |
| Chemical Properties | colorless liquid | | Uses | Methyl tetrahydro-2H-pyran-4-carboxylate may be used in the following syntheses:
- cycloalkylamide derivatives
- tetrahydro-2-furoic chloride
- tetrahydro-2H-pyran-4-carboxylic chloride
| | Synthesis | Tetrahydropyran-4-carboxylic acid (1.00 g, 7.68 mmol) was slowly added to a stirred suspension of anhydrous potassium carbonate (1.17 g, 8.45 mmol) in acetone (40 mL), followed by the dropwise addition of dimethyl sulfate (0.8 mL, 8.45 mmol). The reaction mixture was stirred under heating conditions for 3 hours. After completion of the reaction, the inorganic salts were removed by filtration and the filter cake was washed with acetone. The filtrates were combined, dried and concentrated to afford methyl tetrahydropyran-4-carboxylate (1.1 g, 99% yield), which was used in the subsequent reaction without further purification. The product was analyzed by GC-MS showing m/z 145 (MH+); 1H NMR (300 MHz, CDCl3) δ 1.70-1.80 (m, 4H), 2.47-2.52 (m, 1H), 3.34-3.43 (m, 2H), 3.65 (s, 3H), 3.88-3.95 (m, 2H). | | References | [1] Patent: US2004/224997, 2004, A1. Location in patent: Page 18
[2] Journal of the American Chemical Society, 1993, vol. 115, # 18, p. 8401 - 8408 |
| | Methyl tetrahydropyran-4-carboxylate Preparation Products And Raw materials |
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