- Nifedipine Impurity 57
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- $0.00 / 5mg
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2025-04-16
- CAS:14205-39-1
- Min. Order: 5mg
- Purity: 95%+
- Supply Ability: 1000mg
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| | Methyl 3-aminocrotonate Basic information |
| | Methyl 3-aminocrotonate Chemical Properties |
| Melting point | 81-83 °C(lit.) | | Boiling point | 112°C 42mm | | density | 1.1808 (rough estimate) | | vapor pressure | 2.79-2.853hPa at 25℃ | | refractive index | 1.4538 (estimate) | | Fp | 91 °C | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | 18g/l | | form | Crystalline Powder | | pka | 5.27±0.70(Predicted) | | color | White to slightly yellow | | PH | 8-9 (18g/l, H2O, 20℃) | | Water Solubility | insoluble | | Sensitive | Hygroscopic | | BRN | 956592 | | InChIKey | XKORCTIIRYKLLG-ONEGZZNKSA-N | | LogP | -0.27 at 25℃ | | CAS DataBase Reference | 14205-39-1(CAS DataBase Reference) | | EPA Substance Registry System | 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1) |
| | Methyl 3-aminocrotonate Usage And Synthesis |
| Chemical Properties | Crystals, yellowish-white | | Uses | Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity. | | Uses | Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet | | Uses | Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified. | | Application | Methyl 3-aminocrotonate reacts with benzene to form the corresponding E-2-phenyliodonio tosylate in good yield. This new alkenyl iodonium salt upon reaction with various nucleophiles offers an easy access to substituted enamine derivatives of crotonic acid. The reaction can be also extended to N-substituted crotonates[1]. | | Preparation | 3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists. | | General Description | Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin. | | Flammability and Explosibility | Not classified | | References | [1] IOANNIS PAPOUTSIS; Anastasios V ?; Spyros Spyroudis ?. Reactivity of a new alkenyl phenyliodonium tosylate derived from methyl 3-aminocrotonate[J]. Tetrahedron, 1998. DOI:10.1016/S0040-4020(97)10354-4. |
| | Methyl 3-aminocrotonate Preparation Products And Raw materials |
| Preparation Products | Manidipine-->Amlodipine-->Nitrendipine-->Felodipine-->Benidipine-->Isradipine-->Nisoldipine-->Cilnidipine-->Phthaloyl amlodipine-->Lercanidipine hydrochloride-->2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL--->Methyl 6-chloro-2-Methylnicotinate-->4-(2,3-Dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylic acid-->Felodipine 3,5-DiMethyl Ester-->3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide |
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