- MDL-29951
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- $5.00 / 5KG
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2019-09-04
- CAS:130798-51-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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| | MDL-29951 Basic information |
| Product Name: | MDL-29951 | | Synonyms: | 2-Carboxy-4,6-dichloro-1H-indole-3-propionic acid;3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid;2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid;MDL-29951 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid;MDL-29951, >=98%;3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid;CS-1105;MDL-29951; MDL29951 | | CAS: | 130798-51-5 | | MF: | C12H9Cl2NO4 | | MW: | 302.11 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors | | Mol File: | 130798-51-5.mol |  |
| | MDL-29951 Chemical Properties |
| Melting point | 273-280℃ | | Boiling point | 582.5±45.0 °C(Predicted) | | density | 1.657±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml). | | form | solid | | pka | 4.04±0.30(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| | MDL-29951 Usage And Synthesis |
| Description | NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 μM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair. | | Uses | MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. | | References | 1) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal.,?6?ra93
2) Salituro?et al. (1992)?3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem.,?35?1791 |
| | MDL-29951 Preparation Products And Raw materials |
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