|
|
| | N-(3-BROMOPROPYL)PHTHALIMIDE Basic information |
| | N-(3-BROMOPROPYL)PHTHALIMIDE Chemical Properties |
| Melting point | 72-74 °C(lit.) | | Boiling point | 361℃ | | density | 1.578 | | refractive index | 1.6320 (estimate) | | Fp | 172℃ | | storage temp. | Inert atmosphere,Room Temperature | | solubility | <1g/l | | form | Crystalline Powder or Crystals | | pka | -2.21±0.20(Predicted) | | color | White to light beige | | BRN | 157547 | | InChIKey | VKJCJJYNVIYVQR-UHFFFAOYSA-N | | CAS DataBase Reference | 5460-29-7(CAS DataBase Reference) |
| | N-(3-BROMOPROPYL)PHTHALIMIDE Usage And Synthesis |
| Chemical Properties | white powder | | Uses | N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds. | | Purification Methods | Place it in a Soxhlet and extract it with Et2O, whereby the bis-phthalimido impurity is not extracted. Evaporate the Et2O and recrystallise the residue from EtOH, aqueous EtOH or pet ether. [Gabriel & Weiner Chem Ber 21 2669 1888, Gaudry Can J Chem 31 1060 1953, Beilstein 21/10 V 1277.] |
| | N-(3-BROMOPROPYL)PHTHALIMIDE Preparation Products And Raw materials |
| Preparation Products | N,N-DIBUTYL-1,3-PROPANEDIAMINE-->N-(3-Aminopropyl)morpholine-->N,N-dipropylpropane-1,3-diamine-->1-(3-Aminopropyl)piperidine-->2-[3-(pyridin-2-ylsulfanyl)propyl]-2,3-dihydro-1H-isoindole-1,3-dione-->2-(3-(3,5-Dimethoxyphenoxy)Propyl)Isoindoline-1,3-Dione-->{[3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl]sulfanyl}methanimidamide hydrobromide-->4-[3-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPOXY]BENZALDEHYDE-->ETHYL 2-(3-N-PHTHALIMIDOPROPYL)ACETOACETATE-->Diethyl [3-(N-phthalimido)propyl]phosphonate, 97%-->2-(3-(Methylthio)propyl)isoindoline-1,3-dione |
|