154355-75-6
| 中文名称 | 154355-75-6 |
|---|---|
| 中文同义词 | 化合物 T13263 |
| 英文名称 | ATRELEUTON |
| 英文同义词 | ATRELEUTON;Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-;COX/5-LO-IN-1;Atreleuton analog;COX/5LOIN1,COX/5 LO IN 1 |
| CAS号 | 154355-75-6 |
| 分子式 | C16H15FN2O2S |
| 分子量 | 318.37 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 154355-75-6.mol |
| 结构式 |  |
154355-75-6 性质
| 沸点 | 506.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.63±0.50(Predicted) |
COX/5-LO-IN-1 (Atreleuton analog) 是 cylooxygenase 和 5-lipoxygenase (5-LO) 的抑制剂，用于炎症性和过敏性疾病的研究。
|
5-LO 2 μM (IC 50 ) |
COX
|
COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC 50 of 0.2 μM in human whole blood.