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| | Acotiamide Hydrochloride Basic information |
| Product Name: | Acotiamide Hydrochloride | | Synonyms: | Acotiamide hydrochloride;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride;N-[2-[Bisisopropylamino]-ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide HCl;N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide,hydrochloride;Acotiamide-d6 HCl;N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoy;Acetylformamide hydrochloride;Acotiamide dihydrochloride | | CAS: | 185104-11-4 | | MF: | C21H31ClN4O5S | | MW: | 487.01 | | EINECS: | 203-105-6 | | Product Categories: | | | Mol File: | 185104-11-4.mol |  |
| | Acotiamide Hydrochloride Chemical Properties |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| | Acotiamide Hydrochloride Usage And Synthesis |
| Description | Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. | | Uses | Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia. | | Biological Activity | Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory. |
| | Acotiamide Hydrochloride Preparation Products And Raw materials |
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