ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >HDAC inhibitors >Droxinostat

Droxinostat

Droxinostat Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Droxinostat
CAS:99873-43-5
Purity:0.99 Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:Droxinostat
CAS:99873-43-5
Purity:0.99 Package:5KG;1KG
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:droxinostat
CAS:99873-43-5
Purity:99% Package:1kg
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:Droxinostat
CAS:99873-43-5
Purity:99% Package:1g;1USD
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Products Intro: Product Name:Droxinostat
CAS:99873-43-5
Purity:98% Package:Package as requetsed

Droxinostat manufacturers

  • Droxinostat
  • Droxinostat pictures
  • $1.00 / 1g
  • 2019-12-26
  • CAS:99873-43-5
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 200kg
Droxinostat Basic information
Product Name:Droxinostat
Synonyms:Droxinostat;4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide;NS 41080;ButanaMide, 4-(4-chloro-2-Methylphenoxy)-N-hydroxy-;CS-425;4-(4-Chloro-2-methyl-phenoxy)-N-hydroxy-butyramide;Droxinostat (NS41080);Droxinostat NS41080 NS-41080
CAS:99873-43-5
MF:C11H14ClNO3
MW:243.69
EINECS:
Product Categories:Inhibitors;Inhibitor
Mol File:99873-43-5.mol
Droxinostat Structure
Droxinostat Chemical Properties
density 1.252
storage temp. Inert atmosphere,2-8°C
solubility DMSO: ≥20mg/mL
form powder
color white to off-white
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 26-39
WGK Germany 3
MSDS Information
Droxinostat Usage And Synthesis
UsesDroxinostat is a histone deacetylase selective inhibitor and is used in cancer therapy and cancer research. Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.
DefinitionChEBI: 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide is an aromatic ether.
Biological Activitydroxinostat is a selective inhibitor of hdac3, hdac6, and hdac8 with ic50 value of 16.9 ± 5.0 μm, 2.47 ± 1.09 μm, and 1.46 ± 0.11 μm, respectively [1].hdacs (histone deacetylases) are enzymes responsible of the deacetylation of lysine that residues of core histones and play a pivotal role in controlling chromatin remodeling and transcriptional activation. it is also reported that hdacs control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (hsp90) which is an essential molecular chaperone for fungal virulence and antifungal resistance. multiple hdacs have been identified and hdac1 to hdac10 are shown to express in malignant cells which reminds the hdac inhibitor as a target for cancer therapy [2] [3].droxinostat is a selective hdac inhibitor and is different from the known pan-hdaci tsa which inhibits all tested hdac. when tested with prostate cancer line ppc-1 cells, droxinostat treatment selectively inhibited hdac3, hdac6, and hdac8 activity at the concentration of 50 μm/l which sensitized cells to death ligands [1]. in androgen-dependent cap cells, administration of droxinostat selectively inhibited hdacs and downregulated c-flp expression which resulted in cells apoptosis [4].
targetHDAC8
references[1]. wood, t.e., et al., selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. mol cancer ther, 2010. 9(1): p. 246-56.
[2]. lamoth, f., p.r. juvvadi, and w.j. steinbach, histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. front microbiol, 2015. 6: p. 96.
[3]. mackmull, m.t., et al., histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins. mol cell proteomics, 2015.
[4]. mccourt, c., et al., elevation of c-flip in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy. clin cancer res, 2012. 18(14): p. 3822-33.
Droxinostat Preparation Products And Raw materials
Tag:Droxinostat(99873-43-5) Related Product Information
MONO CHLORO BENZENE Panobinostat Mocetinostat (MGCD0103) Vorinostat Tubastatin-A Entinostat Givinostat (ITF2357)