ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Proteases >Proteasome inhibitors >ONX-0914

ONX-0914

ONX-0914 Suppliers list
Company Name: Changzhou PBpharmaceutical R&D Co.,Ltd
Tel: 0519-83990708
Email: info@pbpharm.com
Products Intro: Product Name:PR 957
CAS:960374-59-8
Purity:98%+ Package:100MG-100KG Remarks:in stock or customized product
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:ONX-0914
CAS:960374-59-8
Purity:0.99summer Package:5KG;1KG Remarks:Summer 618
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:ONX0914 PR-957
CAS:960374-59-8
Purity:99% Package:5KG;1KG Remarks:ONX0914 PR-957
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:ONX-0914 (PR-957)
CAS:960374-59-8
Purity:98% Package:5mg Remarks:V0690
Company Name: Henan Aochuang Chemical Co.,Ltd.
Tel: +86-0371-63689365 +8618638391208
Email: sales@aochuangchem.com
Products Intro: Product Name:ONX-0914
CAS:960374-59-8
Purity:98% Package:1KG;USD|10KG;USD|25KG;USD

ONX-0914 manufacturers

  • ONX-0914
  • ONX-0914 pictures
  • $0.00 / 1KG
  • 2022-10-14
  • CAS:960374-59-8
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1Ton
ONX-0914 Basic information
Product Name:ONX-0914
Synonyms:ONX 0914;PR 957;PR 957(ONX 0914);N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide;L-Tyrosinamide, N-[2-(4-morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-;N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide ONX0914(PR-957);(2S)-3-(4-methoxyphenyl)-N-[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide;ONX-0914, >=99%
CAS:960374-59-8
MF:C31H40N4O7
MW:580.67
EINECS:
Product Categories:Inhibitors
Mol File:960374-59-8.mol
ONX-0914 Structure
ONX-0914 Chemical Properties
Melting point >70oC (dec.)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Pale Yellow
Safety Information
MSDS Information
ONX-0914 Usage And Synthesis
UsesONX 0914 is a proteosome inhibitor known for treatming malignancies and more recently, effacaciously inducing apoptosis for cancers. Used in the treatment of autoimmune diseases.
Biological Activityonx-0914, previously known as pr-975, is a potent inhibitor of immunoproteasome, a form of proteasome generating peptides presented on major histocompatibility complex (mhc) class i molecule to cytotixic t cells, which selectively induces conformational changes in the s1 binding pocket of the immunoproteasome subunit β5i (low molecular mass polypeptide 7/lmp7) rather than the constitutive proteasome subunit β5 in human and mouse cells. onx-0914 is able to block the production of proinflammatory cytokines from human peripheral blood mononuclear cells (pbmcs), activate mouse splenocytes, inhibit il-17-producing t cells under th17-polarizing cytokines in vitro, and attenuate disease progression of diabetes, arthritis, and colitis in mouse models.denise niewerth, niels e. franke, gerrit jansen, yehuda g. assaraf, johan van meerloo, christopher. kirk, jeremiah degenhardt, janet anderl, aaron d. schimmer, sonja zweegman, valerie de haas, terzah m. horton, gertjan j.l. kaspers, and jacqueline cloos. higer ratio immune vs. constitutive proteasome level as novel indicator of sensitivity of pediatric acute leukemia cells to proteasome inhibitors. haematologica 2013.khalid w. kalim, michael basler, christopher j. kirk and marcus groettrup. immunoproteasome subunit lmp7 deficiency and inhibition suppresses th1 and th17 but enhances regulatory t cell differentiation. j immunol 2012; 189:4182-4193
Enzyme inhibitorThis potent protease inhibitor (FW = 580.67 g/mol; CAS 960374-59-8; Solubility: 100 mg/mL DMSO or H2O), also known as PR-957 and N-[2-(4- morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2- oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide, targets (IC50 = 10 nM) the chymotrypsin-like protease activity of immunoproteasomes, a distinct class of proteasome found mainly in monocytes and lymphocytes. These specialized proteasomes shape the antigenic repertoire presented on class I major histocompatibility complexes (MHC-I). ONX-0914 shows minimal cross-reactivity for the constitutive proteasome. Selective inhibition blocks production of Interleukin-23 (IL-23) by activated monocytes and interferon-γ and IL-2 by T cells.
targetLMP7
ONX-0914 Preparation Products And Raw materials
Tag:ONX-0914(960374-59-8) Related Product Information
Bortezomib Y27632 (hydrochloride) Oprozomib Paclitaxel Carfilzomib LY 294002 HYDROCHLORIDE