| Company Name: |
Apicore Pharmaceuticals Pvt Ltd
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+91-2662267177 +91-2662267166 |
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support@apicore.com |
| Products Intro: |
Product Name:Prucalopride hydrochloride
CAS:179474-80-7
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| Company Name: |
ZHIWE CHEMTECH CO LTD
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| Tel: |
021-20221225 13917446399 |
| Email: |
zwchem@163.com |
| Products Intro: |
CAS:179474-80-7
Purity:99% Package:10g
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| | R 093877 Basic information |
| Product Name: | R 093877 | | Synonyms: | R 93877;Prucalopride hydrochloride;Prucalopride HCl;Prucalopride HCl (R-108512, R-93877);4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide:hydrochloride | | CAS: | 179474-80-7 | | MF: | C18H27Cl2N3O3 | | MW: | 404.33 | | EINECS: | | | Product Categories: | | | Mol File: | 179474-80-7.mol |  |
| | R 093877 Chemical Properties |
| | R 093877 Usage And Synthesis |
| Uses | Prucalopride hydrochloride is an orally active, selective and specific 5-HT4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride hydrochloride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride hydrochloride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride hydrochloride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3]. | | References | [1] Chen M, et al. Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway. Hum Exp Toxicol. 2020 Feb;39(2):173-181. DOI:10.1177/0960327119883409
[2] Wang Y, et al. Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats. Int J Mol Med. 2022 Jul;50(1):87. DOI:10.3892/ijmm.2022.5143
[3] Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83. DOI:10.1016/s0014-2999(01)01087-1 |
| | R 093877 Preparation Products And Raw materials |
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