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BIBW2992 DiMaleate

BIBW2992 DiMaleate Suppliers list
Company Name: TianYuan Pharmaceutical CO.,LTD
Tel: +86-755-23284190 13684996853
Email: sales@tianpharm.com
Products Intro: Product Name:Afatinib dimaleate
CAS:850140-73-7
Purity:99% Package:10g 100g 200g 500g 1kg 5kg per barrel
Company Name: Jurong Coupling Biotechnology Co., Ltd.
Tel: 13656108824
Email: coupling278191416@hotmail.com
Products Intro: Product Name:BIBW2992 DiMaleate
CAS:850140-73-7
Purity:99% HPLC Package:5KG;1KG
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Email: sales@frappschem.com
Products Intro: Product Name:Afatinib diMaleate
CAS:850140-73-7
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:BIBW2992 DiMaleate
CAS:850140-73-7
Purity:99%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Afatinib diMaleate
CAS:850140-73-7
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG

Lastest Price from BIBW2992 DiMaleate manufacturers

  • Afatinib dimaleate
  • US $0.00-0.00 / KG
  • 2019-08-16
  • CAS:850140-73-7
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50kg/month
  • BIBW2992 DiMaleate
  • US $7.00 / KG
  • 2019-07-06
  • CAS: 850140-73-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • Afatinib diMaleate
  • US $1.00 / KG
  • 2019-07-06
  • CAS:850140-73-7
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 500kg

Related articles

BIBW2992 DiMaleate Basic information
Description Mechanism of Action
Product Name:BIBW2992 DiMaleate
Synonyms:BAY-2416964;(E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydrofuran-3-yl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide Dimaleate;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate;BIBW2992 DiMaleate;BIBW2992-MA2;Afatinib (diMaleate);Afatinib (diMaleate), BIBW2992;2-ButenaMide, N-[4-[(3-chloro-4-fluorophenyl)aMino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(diMethylaMino)-, (2E)-, (2Z)-2-butenedioate (1:2)
CAS:850140-73-7
MF:C32H33ClFN5O11
MW:718.0827232
EINECS:810-416-1
Product Categories:tyrosine kinase receptor inhibitor;Inhibitors
Mol File:850140-73-7.mol
BIBW2992 DiMaleate Structure
BIBW2992 DiMaleate Chemical Properties
Safety Information
HS Code 29339900
MSDS Information
BIBW2992 DiMaleate Usage And Synthesis
Description

Afatinib dimaleate (Tovok; BIBW2992; Gilotrif) is a salt form of Afatinib. Afatinib is a second-generation, orally administered, irreversible inhibitor of the ErbB family of tyrosine kinases.

Mechanism of Action

Afatinib downregulates ErbB signalling by covalently binding to the kinase domains of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 and HER4, resulting in irreversible inhibition of tyrosine kinase autophosphorylation; it also inhibits transphosphorylation of HER3. Afatinib is approved as monotherapy for the treatment of EGFR tyrosine kinase inhibitor (TKI)-naïve adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating EGFR mutations in the EU, and for the first-line treatment of patients with metastatic NSCLC whose tumours have EGFR exon 19 deletions or exon 21 (L858R) substitution mutations as detected by a US FDA-approved test in the US.

DefinitionChEBI: A maleate salt obtained by combining afatinib with two molar equivalents of maleic acid. Used for the first-line treatment of patients with metastatic non-small cell lung cancer.
BIBW2992 DiMaleate Preparation Products And Raw materials
Tag:BIBW2992 DiMaleate(850140-73-7) Related Product Information
9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride Cabozantinib Malate 918504-65-1 1110813-31-4 Crizotinib PLERIXAFOR 201530-41-8 N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide Nintedanib Ethanesulfonate Salt Olaparib trans-4-Dimethylaminocrotonic acid hydrochloride (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Afatinib 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- (S)-(+)-3-Hydroxytetrahydrofuran Afatinib (BIBW 2992) 7-Fluoro-6-nitro-4-hydroxyquinazoline 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-