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| | A 967079 Basic information |
| Product Name: | A 967079 | | Synonyms: | A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079 | | CAS: | 1170613-55-4 | | MF: | C12H14FNO | | MW: | 207.24 | | EINECS: | | | Product Categories: | Aliphatics, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 1170613-55-4.mol |  |
| | A 967079 Chemical Properties |
| Boiling point | 324.4±34.0 °C(Predicted) | | density | 1.03±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | 2-8°C | | solubility | DMSO: ≥12mg/mL | | pka | 12.23±0.40(Predicted) | | form | powder | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months |
| WGK Germany | 3 | | HS Code | 2928009090 |
| | A 967079 Usage And Synthesis |
| Description | A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable | | Uses | (1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain. | | Uses | A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel. | | General Description | A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury. | | Biochem/physiol Actions | A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation. | | storage | +4°C | | References | 1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14. |
| | A 967079 Preparation Products And Raw materials |
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