WAY 161503盐酸盐
| 中文名称 | WAY 161503盐酸盐 |
|---|---|
| 中文同义词 | WAY 161503盐酸盐;化合物 T13332;化合物(RAC)-WAY-161503 |
| 英文名称 | 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE |
| 英文同义词 | 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE;WAY 161503 HYDROCHLORIDE;WAY 161503;1H-Pyrazino[1,2-a]quinoxalin-5(6H)-one, 8,9-dichloro-2,3,4,4a-tetrahydro-;WAY 161503 hydrochlo;(Rac) WAY 161503,(Rac)WAY161503 |
| CAS号 | 75704-24-4 |
| 分子式 | C11H11Cl2N3O |
| 分子量 | 272.13 |
| EINECS号 | |
| 相关类别 | Serotonin receptor |
| Mol文件 | 75704-24-4.mol |
| 结构式 |  |
WAY 161503盐酸盐 性质
| 沸点 | 513.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 储存条件 | Desiccate at RT |
| 溶解度 | DMF：30mg/mL； DMF:PBS(pH 7.2)(1:1)：0.5 mg/ml； DMSO：25mg/mL；乙醇：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 12.09±0.20(Predicted) |
WAY 161503盐酸盐是一种有效的、选择性的、高亲和力的 5-HT2C 受体激动剂，具有抗肥胖和抗抑郁的作用。
|
5-HT 2C Receptor 4 nM (Ki) |
5-HT 2C Receptor 12 nM (EC 50 ) |
(Rac)-WAY-161503 (3-30 mg/kg; intraperitoneal injection; male C57BL/6J mice) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT 2C/2B antagonist SER-082. Additionally, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated in the 5-HT 2A KO mice.
| Animal Model: | Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) |
| Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT 2C/2B antagonist SER-082. |