- 5’O-Tritylinosine
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- $0.00 / 1G
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2025-09-23
- CAS:4152-77-6
- Min. Order: 1G
- Purity: 98%
- Supply Ability: 2000
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| | 5’O-Tritylinosine Basic information |
| Product Name: | 5’O-Tritylinosine | | Synonyms: | 5’O-Tritylinosine;KIN-59;Inosine, 5'-O-(triphenylmethyl)-;5'-O-tritylinosine-2'-deoxyinosine;5'-O-Trt-rI;5’-O-Tritylinosine;5′-O-Tritylinosine, CAS 4152-77-6 | | CAS: | 4152-77-6 | | MF: | C29H26N4O5 | | MW: | 510.54 | | EINECS: | | | Product Categories: | | | Mol File: | 4152-77-6.mol |  |
| | 5’O-Tritylinosine Chemical Properties |
| solubility | DMF: 5 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.3 mg/mL | | form | A crystalline solid | | color | White to off-white | | InChIKey | YEPZMZDCXFRHCL-ZYWWQZICSA-N | | SMILES | O(C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)O)N=C2)[C@H](O)[C@@H]1O |
| | 5’O-Tritylinosine Usage And Synthesis |
| Description | KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50s = 44 and 67 μM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice. | | Uses | 5’O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. | | Uses | 5’-O-Tritylinosine acts as an allosteric inhibitor of angiogenic enzyme thymidine phosphorylase. | | in vivo | KIN59 (15 mg/kg; s.c.; twice daily from day 2 for 20 days) shows anti-tumor activity in mice[1]. | Animal Model: | Eight-week-old female, 25 g, athymic, nude nu/nu mice (F2T-luc2.9 cellss)[1] | | Dosage: | 15 mg/kg | | Administration: | S.c.; twice daily from day 2 (once daily during the weekend) at a site distant from the tumor (inoculation) site for 20 days | | Result: | Caused a significant inhibition in the rate of tumor growth. |
| | References | [1] SANDRA LIEKENS. The nucleoside derivative 5’-O-trityl-inosine (KIN59) suppresses thymidine phosphorylase-triggered angiogenesis via a noncompetitive mechanism of action.[J]. The Journal of Biological Chemistry, 2004, 279 28: 29598-29605. DOI: 10.1074/jbc.m402602200
[2] SANDRA LIEKENS. 5’-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis.[J]. Molecular Pharmacology, 2006, 70 2: 501-509. DOI: 10.1124/mol.105.021188
[3] SANDRA LIEKENS. The thymidine phosphorylase inhibitor 5’-O-tritylinosine (KIN59) is an antiangiogenic multitarget fibroblast growth factor-2 antagonist.[J]. Molecular Cancer Therapeutics, 2012, 11 4: 817-829. DOI: 10.1158/1535-7163.mct-11-0738 |
| | 5’O-Tritylinosine Preparation Products And Raw materials |
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