AZD-3965

AZD-3965 Suppliers list
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:AZD3965
CAS:733809-45-5
Purity:2.0M in THF Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Email: sales@boylechem.com
Products Intro: Product Name:AZD-3965
CAS:733809-45-5
Company Name: Shanghai YuanQi Biotechnology Co., Ltd.  
Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Products Intro: Product Name:AZD3965
CAS:733809-45-5
Purity:>98% Package:5mg/;10mg/;50mg/;100mg/
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 17754423994 17754423994
Email: 2853530910@QQ.com
Products Intro: Product Name:AZD3965
CAS:733809-45-5
Purity:98% HPLC LCMS Package:100mg;1g
Company Name: Shanghai Biopharmaleader Co., Ltd.  
Tel: +86 18721201413
Email: sales@biopharmaleader.com
Products Intro: Product Name:AZD-3965
CAS:733809-45-5
Purity:98%HPLC Package:10g,100g
AZD-3965 Basic information
Product Name:AZD-3965
Synonyms:AZD-3965;5-[[(4S)-4-Hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;(S)-5-(4-hydroxy-4-methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione;Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5-[[(4S)-4-hydroxy-4-methyl-2-isoxazolidinyl]carbonyl]-3-methyl-1-(1-methylethyl)-6-[[3-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-
CAS:733809-45-5
MF:C21H24F3N5O5S
MW:515.51
EINECS:
Product Categories:
Mol File:733809-45-5.mol
AZD-3965 Structure
AZD-3965 Chemical Properties
Melting point >140°C (dec.)
Boiling point 723.1±70.0 °C(Predicted)
density 1.483±0.06 g/cm3(Predicted)
storage temp. -20°C, Inert atmosphere
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Solid
pka10.92±0.50(Predicted)
color Off-White to Pale Yellow
Safety Information
MSDS Information
AZD-3965 Usage And Synthesis
UsesAZD 3965 is a monocarboxylate transporter 1 (MCT1) inhibitor.
Enzyme inhibitorThis orally bioavailable MCT1 inhibitor (FW = 515.51 g/mol; CASs = 733809-45-5 and 1448671-31-5), also named (S)-5-(4-hydroxy-4- methylisoxazolidine-2-carbonyl)-1-isopropyl-3-methyl-6-((3-methyl-5-(tri fluoromethyl)-1H-pyrazol-4-yl)methyl)-thieno[2,3-d]pyrimidine-2,4(1H, 3H) -dione, selectively targets the Monocarboxylate Transporter-1 (IC50 = 1.6 nM) and is ~6x less active toward MCT2. AZD3965 does not inhibit MCT4, even at 10 μM. MCT1 and MCT4 are primarily involved in lactate transport, targeting highly glycolytic cancer cells, especially those that are hypoxic. The latter property suggests that the combined use with a vascular-disrupting anticancer agent (such as combrestatin) may improve the inhibitory action of AZD-3965 against cancer cells.
AZD-3965 Preparation Products And Raw materials
Tag:AZD-3965(733809-45-5) Related Product Information
GSK-2126458