- PU-WS13
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- $1.00 / 1KG
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2019-07-06
- CAS:1454619-14-7
- Min. Order: 1KG
- Purity: 98-100%
- Supply Ability: 1000kg
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| | PU-WS13 Basic information |
| Product Name: | PU-WS13 | | Synonyms: | PU-WS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine;PU WS13;PUWS13;CS-1689;CS-2047;9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)- | | CAS: | 1454619-14-7 | | MF: | C17H20Cl2N6S | | MW: | 411.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1454619-14-7.mol |  |
| | PU-WS13 Chemical Properties |
| Boiling point | 617.4±65.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL | | form | Powder | | pka | 10.15±0.29(Predicted) |
| | PU-WS13 Usage And Synthesis |
| Description | PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells. | | Uses | PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments. |
| | PU-WS13 Preparation Products And Raw materials |
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