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N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate

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N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Package:10 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:>=98% Package:$35.9/1mg;$137.9/5mg;$211.9/10mg;$476.9/25mg;$853.9/50mg;$1535.9/100mg;$3455.9/2 Remarks:98%
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: MQ (shanghai) Pharmaceuticals Co., Ltd.  
Tel: 13761635123
Email: 1014988033@qq.com
Products Intro: Product Name:N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
CAS:675599-62-9
Purity:＞95% Package:1G,5G
Company Name: BOC Sciences  
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Email: info@bocsci.com
Products Intro: Product Name:PG 01037 dihydrochloride
CAS:675599-62-9
Purity:≥98% Remarks:PG 01037 dihydrochloride is a dopamine D3 receptor antagonist, which is more selective for D3 receptors than other D3 antagonists that are currently available with a D2/D3 selectivity ratio of 867 and
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Basic information
Product Name:N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate
Synonyms:N-[(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridyl)benzamide dihydrochloride hydrate;N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate;PG01037 dihydrochloride hydrate;PG-01037 (hydrochloride)
CAS:675599-62-9
MF:C26H30Cl4N4O2
MW:572.354
EINECS:
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Mol File:675599-62-9.mol
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Structure
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Chemical Properties
Melting point 230-232 °C(Solv: isopropanol (67-63-0))
storage temp. 2-8°C
solubility H2O: ≥8mg/mL at ~60°C
form powder
color white to tan
Safety Information
WGK Germany 3
MSDS Information
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Usage And Synthesis
DescriptionPG-01037 is a selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively). It inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM). PG-01037 (32 mg/kg) reduces progressive-ratio methamphetamine self-administration in rats allowed extended access. It reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of Parkinson''s disease induced by MPTP.
UsesPG01037 dihydrochloride is a selective D3DR antagonist.
storageDesiccate at +4°C
N-{4-[4-(2,3-Dichlorophenyl)-piperazin-1-yl]-trans-but-2-enyl}-4-(pyridin-2-yl)benzamide dihydrochloride hydrate Preparation Products And Raw materials
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