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| | CK-0157869 Basic information |
| Product Name: | CK-0157869 | | Synonyms: | 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone;CK 869;CK-0157869;CK-869;CS-2870;CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869;4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)-;CK869,Arp2/3 Complex,inhibit,CK-869,Inhibitor,CK 869,Actin-related protein 2/3 complex | | CAS: | 388592-44-7 | | MF: | C17H16BrNO3S | | MW: | 394.28 | | EINECS: | | | Product Categories: | | | Mol File: | 388592-44-7.mol |  |
| | CK-0157869 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | color | white to light gray |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | WGK Germany | 3 |
| | CK-0157869 Usage And Synthesis |
| Description | CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells. | | Uses | CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells. | | Uses | CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
- to induce membrane blebbing in HT1080 fibrosarcoma cells
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
| | Biochem/physiol Actions | CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex. |
| | CK-0157869 Preparation Products And Raw materials |
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