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| | Phenformin hydrochloride Basic information |
| Product Name: | Phenformin hydrochloride | | Synonyms: | 1-(diaminomethylene)-2-phenethylguanidine hydrochloride;1-(diaminomethylene)-2-phenethyl-guanidine hydrochloride;1-(diaminomethylidene)-2-phenethylguanidine hydrochloride;1-(diaminomethylidene)-2-phenethyl-guanidine hydrochloride;1-Fenetilbiguanide cloridrato [Italian];1-Phen;meltrol;n-(2-phenylethyl)-imidodicarbonimidicdiamidmonohydrochloride | | CAS: | 834-28-6 | | MF: | C10H16ClN5 | | MW: | 241.72 | | EINECS: | 212-637-3 | | Product Categories: | Inhibitors;API;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 834-28-6.mol |  |
| | Phenformin hydrochloride Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | DU2200000 | | HS Code | 29252900 | | Toxicity | LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske) |
| | Phenformin hydrochloride Usage And Synthesis |
| Description | Phenformin is an orally administered biguanide derivative with potential to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus. In general, biguanides improve insulin sensitivity and decrease insulin resistance by inhibiting complex 1 of the mitochondrial respiratory chain and inducing AMP-activated protein kinase (AMPK)-dependent signaling. Phenformin, however, has been withdrawn from clinical use because it also inhibits peripheral glucose oxidation and has an associated effect of inducing lactic acidosis when not metabolized sufficiently. Through AMPK activation, phenformin at 300 mg/kg exhibits anticancer activity by inhibiting the growth of MCF-7 and MDAMB231 breast cancer cell xenografts in mice. | | Chemical Properties | White Crystalline Solid | | Uses | It is an anti-diabetic drug from the biguanide class. | | Uses | erectile dysfunction therapy | | Brand name | DBI (Ciba-Geigy). | | General Description | White solid or powder. Formerly used as an anti-diabetic drug. Toxic (causes lactic acidosis. | | Air & Water Reactions | Water soluble. | | Reactivity Profile | Phenformin hydrochloride gives weakly acidic aqueous solutions. May react with strong oxidizing agents. | | Fire Hazard | Flash point data for Phenformin hydrochloride are not available; however, Phenformin hydrochloride is probably combustible. | | Safety Profile | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx. |
| | Phenformin hydrochloride Preparation Products And Raw materials |
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