| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:TYRPHOSTIN B7
CAS:134036-53-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Email: |
marketing_china@spectrumchemical.com |
| Products Intro: |
Product Name:Tyrphostin AG 370
CAS:134036-53-6
Package:1MG Remarks:T3276
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:AG-370
CAS:134036-53-6
Purity:95% Package:1G;10G;100G
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| | TYRPHOSTIN B7 Basic information |
| Product Name: | TYRPHOSTIN B7 | | Synonyms: | AG 370;2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7;TYROPHOSTIN AG 370;TYRPHOSTIN B7;TYRPHOSTIN AG 370;3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE;2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE | | CAS: | 134036-53-6 | | MF: | C15H9N5 | | MW: | 259.27 | | EINECS: | | | Product Categories: | | | Mol File: | 134036-53-6.mol |  |
| | TYRPHOSTIN B7 Chemical Properties |
| Boiling point | 714.1±60.0 °C(Predicted) | | density | 1.396±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: soluble | | pka | 15.95±0.30(Predicted) | | form | Yellow solid. |
| | TYRPHOSTIN B7 Usage And Synthesis |
| Description | Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-derived growth factor (PDGF) by blocking the phosphorylation of specific tyrosine residues. AG-370 is a selective inhibitor of PDGF receptor kinase with an IC50 value of 20 μM in human bone marrow fibroblasts. It displays comparatively weak inhibition of the EGF receptor (IC50 = 820 μM). | | Definition | ChEBI: AG-370 is a member of indoles. | | in vitro | previous study found that ag-370 inhibited pdgf receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the pdgf receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. when compared with ag18, a potent egf receptor blocker, ag370 was more efficient in inhibiting pdgf-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. under the conditions in which ag370 could inhibit pdgf-induced mitogenesis and phosphorylation, ag18 did not alter [125i]pdgf internalization and enhance [125i]pdgf binding. these findings suggested that ag370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by pdgf [1]. | | IC 50 | 20 μm for pdgf receptor kinase in human bone marrow fibroblasts | | references | [1] bryckaert, m. c.,eldor, a.,fontenay, m., et al. inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. experimental cell research 199, 255-261 (1992). |
| | TYRPHOSTIN B7 Preparation Products And Raw materials |
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