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| | GW806742X Basic information |
| Product Name: | GW806742X | | Synonyms: | GW806742X;3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide;GW806742X >=98% (HPLC);Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-;GW806742X ≥95%;1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea;GW806742X;GW-806742X;GW 806742X;CS-2659 | | CAS: | 579515-63-2 | | MF: | C25H22F3N7O4S | | MW: | 573.55 | | EINECS: | | | Product Categories: | | | Mol File: | 579515-63-2.mol |  |
| | GW806742X Chemical Properties |
| density | 1.524±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM) | | pka | 10.09±0.60(Predicted) |
| | GW806742X Usage And Synthesis |
| Biological Activity | GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis. | | in vitro | GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM. | | target | | MLKL 9.3 μM (Kd) | VEGFR2 2 nM (IC 50 < /sub> ) | |
| | GW806742X Preparation Products And Raw materials |
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