ChemicalBook > Product Catalog >Biochemical Engineering >Natural Products >Verbascoside

Verbascoside

Verbascoside Suppliers list
Company Name: Shanghai Standard Technology Co., Ltd.
Tel: 18502101150
Email: ft-sales@nature-standard.com
Products Intro: Product Name:Acteoside
CAS:61276-17-3
Purity:Analytical Standard Package:20mg;0USD
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Verbascoside
CAS:61276-17-3
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:61276-17-3
CAS:61276-17-3
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Acteoside
CAS:61276-17-3
Purity:HPLC>=98% Package:20mg/200mg
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: 18080483897
Email: maggie@biopurify.com
Products Intro: Product Name:Acteoside
CAS:61276-17-3
Purity:90%~98% HPLC Package:20mg;100mg;500mg;1g Remarks:BP0124

Lastest Price from Verbascoside manufacturers

  • Acteoside
  • US $0.00 / mg
  • 2020-05-11
  • CAS:61276-17-3
  • Min. Order: 5mg
  • Purity: Analytical Standard
  • Supply Ability: 10 g
  • Acteoside
  • US $0.00 / mg
  • 2020-05-11
  • CAS:61276-17-3
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
Verbascoside Basic information
Description Natural occurrences Mechanism of action
Product Name:Verbascoside
Synonyms:glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos;ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,;Acetoside;Extract from Verbena minutiflora (B864379);[(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate;VERBASCOSIDE WITH HPLC;2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate];3,4-Dihydroxyphenethyl alcohol acteoside
CAS:61276-17-3
MF:C29H36O15
MW:624.59
EINECS:
Product Categories:reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chemical reagent;pharmaceutical intermediate;phytochemical;Miscellaneous Natural Products
Mol File:61276-17-3.mol
Verbascoside Structure
Verbascoside Chemical Properties
Melting point 232℃
Boiling point 908.8±65.0 °C(Predicted)
density 1.60±0.1 g/cm3(Predicted)
storage temp. room temp
pka9.31±0.10(Predicted)
InChIKeyFBSKJMQYURKNSU-ZLSOWSIRSA-N
CAS DataBase Reference61276-17-3(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 2
RTECS LZ5786000
HS Code 29389090
ToxicityLD50 oral in rat: > 5gm/kg
MSDS Information
Verbascoside Usage And Synthesis
Description

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Natural occurrences

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

Mechanism of action

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Chemical PropertiesWhite solid
Enzyme inhibitorThis plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
Verbascoside Preparation Products And Raw materials
Tag:Verbascoside(61276-17-3) Related Product Information
ECHINACOSIDE CAMPNEOSIDE I CISTANOSIDE D MARTYNOSIDE 6-O-ACETYLACTEOSIDE Forsythoside B CISTANOSIDE C Verbascoside Cabergoline 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL STEVIA Dihydroergotoxine mesylate Ethoxy β-Glucosidase from sweet almond Alkyl polyglucoside glycoside VERBASCOSE Nicergoline