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LEVOCABASTINE

LEVOCABASTINE Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:levocabastine
CAS:79516-68-0
Purity:0.99 Package:1kg
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569265 +86-15319487004
Email: 1015@dideu.com
Products Intro: Product Name:Levocabastine
CAS:79516-68-0
Purity:99% Package:1g;1USD|10g;1USD|100g;1USD|1KG;1USD|25KG;1USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
Email: 1026@dideu.com
Products Intro: Product Name:LEVOCABASTINE USP/EP/BP
CAS:79516-68-0
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Levocabastine;Livostin;Bilina
CAS:79516-68-0
Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hu Bei Jiutian Bio-medical Technology CO.,Ltd
Tel: 027-88013699 17354350817
Email: Ryan@jiutian-bio.com
Products Intro: Product Name:Levocabastine
CAS:79516-68-0
Purity:0.99 Package:25kg,50kg,180kg,200kg,250kg,1000kg,as your needs Remarks:as your needs

LEVOCABASTINE manufacturers

  • Levocabastine
  • Levocabastine pictures
  • $1.00 / 1g
  • 2021-07-20
  • CAS:79516-68-0
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
LEVOCABASTINE Basic information
Product Name:LEVOCABASTINE
Synonyms:Levocabastine & Levocabastine Hydrochloride;(3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;(3S,4R)-1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-Methyl-4-phenylpiperidine-4-carboxylic acid;LEVOCABASTINE;4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, [3S-[1(cis),3a,4b]]-;4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, (3S,4R)- (9CI);(3S)-1-[4α-Cyano-4-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4-phenylpiperidine-4α-carboxylic acid;(3S)-1-[4α-Cyano-4β-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4β-phenyl-4α-piperidinecarboxylic acid
CAS:79516-68-0
MF:C26H29FN2O2
MW:420.52
EINECS:
Product Categories:
Mol File:79516-68-0.mol
LEVOCABASTINE Structure
LEVOCABASTINE Chemical Properties
Boiling point 589.9±50.0 °C(Predicted)
density 1.23
pka3.57±0.40(Predicted)
Safety Information
MSDS Information
LEVOCABASTINE Usage And Synthesis
OriginatorLivostin,Janssen-Cilag,Belgium
UsesAnti histaminic.
DefinitionChEBI: Levocabastine is a member of piperidines.
Manufacturing Process4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)
Brand nameLivostin (Novartis).
Therapeutic FunctionAntihistaminic
LEVOCABASTINE Preparation Products And Raw materials
Raw materialsEthyl acrylate-->4-Fluorophenylacetonitrile-->Sodium Methoxide
Tag:LEVOCABASTINE(79516-68-0) Related Product Information
Antazoline Pirenoxine 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 1-(4-FLUOROPHENYL)CYCLOHEXANECARBONITRILE 1-Phenyl-1-cyclohexanecarbonitrile 4-Fluorophenylacetonitrile 4-Phenylcyclohexanamine LEVOCABASTINE LEVOCABASTINE IMPURITY D 4-Piperidinecarboxylicacid,1-(1-methylethyl)-(9CI) 4-Piperidinemethanol,1-(1-methylethyl)-(9CI) (αS)-α-Isopropylbenzeneacetic acid PETHIDINIC ACID 5-Piperidinovaleronitrile Cabastine 4-phenyl-1-(4-phenylbutyl)piperidine