| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:GS 39783
CAS:39069-52-8
Package:100Mg,10Mg,50Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:GS 39783;N,N'-Dicyclopentyl-2-(Methylthio)-5-nitro-4,6-pyriMidinediaMine
CAS:39069-52-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | GS 39783 Basic information |
| Product Name: | GS 39783 | | Synonyms: | N,N'-DICYCLOPENTYL-2-METHYLSULFANYL-5-NITRO-PYRIMIDINE-4,6-DIAMINE;N,N'-DICYCLOPENTYL-2-(METHYLTHIO)-5-NITRO-4,6-PYRIMIDINEDIAMINE;GS 39783;N,N'-Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediaamine;N4,N6-Dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine;4,6-Pyrimidinediamine, N4,N6-dicyclopentyl-2-(methylthio)-5-nitro- | | CAS: | 39069-52-8 | | MF: | C15H23N5O2S | | MW: | 337.44 | | EINECS: | | | Product Categories: | GABA/Glycine receptor | | Mol File: | 39069-52-8.mol |  |
| | GS 39783 Chemical Properties |
| storage temp. | Store at RT | | solubility | DMSO: ~8 mg/mL | | form | powder | | color | yellow |
| | GS 39783 Usage And Synthesis |
| Uses | GS 39783 is an allosteric positive modulator of GABAB receptors. GS 39783 attenuates acute cocaine-induced hyperlocomotion and blocks cocaine-induced Fos induction in the striatal complex. | | Definition | ChEBI: N4,N6-dicyclopentyl-2-(methylthio)-5-nitropyrimidine-4,6-diamine is an aryl sulfide. | | Biological Activity | Novel positive allosteric modulator of GABA B receptor function. Potentiates the effects of GABA on [ 35 S]GTP γ S binding at recombinant and native GABA B receptors (EC 50 values are 2.1 and 3.1 μ M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines. | | storage | Store at RT |
| | GS 39783 Preparation Products And Raw materials |
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