DBCO-PEG4-NH-Boc manufacturers
- DBCO-NHCO-PEG4-NHBoc
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- $0.00 / 50mg
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2025-06-07
- CAS:1255942-12-1
- Min. Order: 50mg
- Purity: >95.00%
- Supply Ability: 250mg
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| | DBCO-PEG4-NH-Boc Basic information |
| Product Name: | DBCO-PEG4-NH-Boc | | Synonyms: | DBCO-PEG4-NH-Boc;DBCO-NHCO-PEG4-NH-Boc;DBCO-NHCO-PEG4-t-Boc Amine;5,8,11,14-Tetraoxa-2,18-diazaheneicosanoic acid, 21-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 1,1-dimethylethyl ester;5,8,11,14-Tetraoxa-2,18-diazaheneicosanoic acid, 21-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,21-dioxo-, 1,1-dimethylethyl ester (ACI) | | CAS: | 1255942-12-1 | | MF: | C34H45N3O8 | | MW: | 623.74 | | EINECS: | | | Product Categories: | | | Mol File: | 1255942-12-1.mol |  |
| | DBCO-PEG4-NH-Boc Chemical Properties |
| Boiling point | 840.5±65.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | form | Viscous Liquid | | pka | 12.23±0.46(Predicted) | | color | Colorless to yellow |
| | DBCO-PEG4-NH-Boc Usage And Synthesis |
| Description | DBCO-NHCO-PEG4-NH-Boc is a click chemistry reagent. it can undergo copper-free Click Chemistry reactions with azides. The Boc protecting group can be removed under acidic conditions. | | Biological Activity | DBCO-NHCO-PEG4-NH-Boc is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Cleavable | PEGs | Alkyl/ether | |
| | DBCO-PEG4-NH-Boc Preparation Products And Raw materials |
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