D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷
| 中文名称 | D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷 |
|---|---|
| 中文同义词 | D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷;硫代半乳糖苷;(D-GALACTOPYRANOSYL)-B-D-THIOGALACTOPYRANOSIDE 硫代二半乳糖苷;N4苯甲酰基5'-O-DMT-5-甲基;(2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫基双(2-(羟甲基)四氢-2H-吡喃-3,4,5-三醇);硫代半乳糖苷,10 MM DMSO 溶液;(2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫基双(2-(羟甲基)四氢-2H-吡喃-3,4,5-三醇);D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷 |
| 英文名称 | Thiodigalactoside |
| 英文同义词 | D-GALACTOPYRANOSYL BETA-D-THIOGALACTOPYRANOSIDE;d-galactopyranosyl-β-d-thiogalactopyranoside;D-Galactopyranosyl-b-D-thiogalactopyranoside;D-Galactopyranosyl-β-D-thiogalactopyranoside ,98%;Galactosyl 1-thiogalactoside;β-D-Galactopyranoside, β-D-galactopyranosyl 1-thio-;(2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-Thiobis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol);Thiodigalactoside, 10 mM in DMSO |
| CAS号 | 51555-87-4 |
| 分子式 | C12H22O10S |
| 分子量 | 358.36 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 51555-87-4.mol |
| 结构式 |  |
D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷 性质
| 熔点 | >225°C (dec.) |
|---|---|
| 沸点 | 712.565±60.00 °C(Press: 760.00 Torr)(predicted) |
| 密度 | 1.779±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | −20°C |
| 溶解度 | 二甲基亚砜（微溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 12.629±0.70(predicted) |
| 颜色 | 白色 |
| 水溶解性 | H2O: 2mg/mL, clear |
| InChI | InChI=1/C12H22O10S/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8+,9-,10-,11+,12/s3 |
| InChIKey | SYKYBMOFPMXDRQ-YSLNCGCNNA-N |
| SMILES | C1([C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O)S[C@H]1[C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O |&1:1,3,4,6,12,13,15,16,18,r| |
Thiodigalactoside (TDG) 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 Kd 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。
Kd: 24 μM (GAL1) and 49 μM (GAL3)
Thiodigalactoside (TDG; 250 and 500 μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining.
Thiodigalactoside (TDG; 5 mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain.
Thiodigalactoside (5 mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p..
| Animal Model: | Five-week-old Sprague-Dawley (SD) male rats |
| Dosage: | 5 mg/kg |
| Administration: | IP; once per week for 5 weeks |
| Result: | Resulted in dramatic inhibition of HFD-induced body weight gain by inhibiting adipogenesis and lipogensis as well as by increasing expression of the proteins associated with thermogenesis and energy expenditure. |
安全信息
| WGK Germany | 3 |
|---|---|
| 海关编码 | 29389090 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-130208 | D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷 Thiodigalactoside | 51555-87-4 | 5 mg | 253元 |
| 2026/09/15 | HY-130208 | D-吡喃半乳糖 Β-D-硫代吡喃半乳糖苷 Thiodigalactoside | 51555-87-4 | 10mM * 1mLin Water | 278元 |