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LITHOCHOLIC ACID

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Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:LITHOCHOLIC ACID
CAS:434-13-9
Purity:99% Package:9700/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
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Products Intro: Product Name:LITHOCHOLIC ACID
CAS:434-13-9
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:434-13-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:LITHOCHOLIC ACID
CAS:434-13-9
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Products Intro: CAS:434-13-9

Lastest Price from LITHOCHOLIC ACID manufacturers

  • LITHOCHOLIC ACID
  • US $1.00 / KG
  • 2019-05-13
  • CAS: 434-13-9
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 100KG
LITHOCHOLIC ACID Basic information
Product Name:LITHOCHOLIC ACID
Synonyms:Lithocolic acid;NCI-C03861;3α-Hydroxy-5β-cholan-24-oic acid;3α-Hydroxy-5β-cholanic acid;5β-Cholan-24-oic acid-3α-ol;(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,];LITHOCHOLIC ACID(RG);3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
CAS:434-13-9
MF:C24H40O3
MW:376.57
EINECS:207-099-1
Product Categories:Steroids;Bile Acids;Biochemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
Mol File:434-13-9.mol
LITHOCHOLIC ACID Structure
LITHOCHOLIC ACID Chemical Properties
Melting point 183-188 °C(lit.)
alpha D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
Boiling point 445.09°C (rough estimate)
density 1.0454 (rough estimate)
refractive index 35.5 ° (C=1, EtOH)
Fp 9℃
storage temp. Refrigerator
form Powder
color White to off-white
Merck 5545
BRN 3217757
InChIKeySMEROWZSTRWXGI-HVATVPOCSA-N
CAS DataBase Reference434-13-9(CAS DataBase Reference)
Safety Information
Safety Statements 22-24/25
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 2
RTECS FZ2275000
HS Code 29181998
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
LITHOCHOLIC ACID Usage And Synthesis
Chemical Propertieswhite to off-white powder
UsesA cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.
UsesLD50(mouse) 3900 mg/kg po
UsesCholagogue;Anticholelithogenic
DefinitionChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
General DescriptionHexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.
Air & Water ReactionsInsoluble in water.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes.
Fire HazardFlash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible.
Purification MethodsLithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]
LITHOCHOLIC ACID Preparation Products And Raw materials
Tag:LITHOCHOLIC ACID(434-13-9) Related Product Information
DEOXYCHOLIC ACID SODIUM SALT MONOHYDRATE LABOTEST-BB LT00454505 CHENODEOXYCHOLIC ACID SODIUM SALT 3ALPHA,7ALPHA-DIACETOXY-5BETA-CHOLAN-24-OIC ACID METHYL ESTER 5B-CHOLANIC ACID-3A-OL-12-ONE3-BENZOATE METHYL EST SODIUMLITHOCHOLATE HYODEOXYCHOLIC ACID SODIUM SALT Sodium cholate 3α,12α-Diacetoxy-5β-cholan-24-oic acid methyl ester 12-DEHYDROCHOLIC ACID METHYL ESTER Sodium deoxycholate 5BETA-CHOLANIC ACID-3ALPHA,12ALPHA-DIOL 3-CARBETHOXYLATE METHYL ESTER 3-ALPHA-HYDROXY-6-KETOCHOLANIC ACID METHYL DESOXYCHOLATE LITHOCHOLIC ACID ACETATE URSODEOXYCHOLIC ACID SODIUM SALT HYODEOXYCHOLIC ACID METHYL ESTER LITHOCHOLIC ACID