(R)-(+)-WARFARIN

(R)-(+)-WARFARIN Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:(R)-(+)-Warfarin
CAS:5543-58-8
Purity:0.99 Package:1kg
Company Name: Hebei Duling International Trade Co. LTD
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Products Intro: Product Name:(R)-(+)-WARFARIN
CAS:5543-58-8
Company Name: China National Standard Pharmaceutical Corporation Limited
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Products Intro: Product Name:Warfarin Impurity 16(Warfarin R-Isomer)
CAS:5543-58-8
Purity:0.95 Package:Vials
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
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Products Intro: Product Name:R-(+)-Warfarin
CAS:5543-58-8
Package:50Mg,5Mg
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-chromen-2-one
CAS:5543-58-8
Purity:98%+
(R)-(+)-WARFARIN Basic information
Product Name:(R)-(+)-WARFARIN
Synonyms:4-Hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one;(R)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone;(S)-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin;r-(+)-3-acetonybenzyl)-4-hydroxycoumarin;2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, (R)-;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]- (9CI);Coumarin, 3-(a-acetonylbenzyl)-4-hydroxy-, R-(+)- (8CI);Dextrowarfarin
CAS:5543-58-8
MF:C19H16O4
MW:308.33
EINECS:226-908-9
Product Categories:Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:5543-58-8.mol
(R)-(+)-WARFARIN Structure
(R)-(+)-WARFARIN Chemical Properties
Melting point ≥170 °C
Boiling point 515.2±50.0 °C(Predicted)
density 1.307±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: soluble
form A crystalline solid
pka4.50±1.00(Predicted)
color white to pale yellow
Safety Information
Hazard Codes T
Risk Statements 61-48/25-52/53
Safety Statements 53-45-61
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
(R)-(+)-WARFARIN Usage And Synthesis
Chemical PropertiesWhite Solid
UsesThe R-(+)-form of Warfarin (W498500). Coumarin anticoagulant.
Uses(R)-(+)-warfarin has been used to investigate whether enantiomers of warfarin stereoselectively interact with pregnane X nuclear receptor (PXR) to upregulate main drug/xenobiotic-metabolizing enzymes cytochrome P450 3A4 (CYP3A4) and cytochrome P450 2C9 (CYP2C9). It has also been used in HepG2 cells to study protein profiles
DefinitionChEBI: (R)-warfarin is a 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one that has (R)-configuration (the racemate is warfarin, an anticoagulant drug and rodenticide). It is a conjugate acid of a (R)-warfarin(1-). It is an enantiomer of a (S)-warfarin.
General DescriptionThe chiral carbon at position 9 produces two enantiomers, R- and S-warfarin. Commercially available warfarin (Coumadin or Jantoven) is a racemic mixture of S- and R-enantiomers.
Biochem/physiol ActionsWarfarin acts as a vitamin K antagonist. It is widely used to treat thromboembolic disorders. (R)-warfarin interacts with pregnane X receptor (PXR) and induces cytochrome P450 3A4 (CYP3A4) and CYP2C9 mRNAs expression in primary human hepatocyte cultures.
(R)-(+)-WARFARIN Preparation Products And Raw materials
Tag:(R)-(+)-WARFARIN(5543-58-8) Related Product Information
Warfarin 4-Hydroxycoumarin 4,4'-(Disulfanediyl)bis(2,6-di-tert-butylphenol) (S)-8-Hydroxy Warfarin (R)-6-Hydroxy Warfarin 3-(o-Hydroxyphenyl)-5-phenyl-2-cyclohexen-1-one Benzalacetone 3-[α-(2-Hydroxypropyl)benzyl]-4-hydroxycouMarin (R)-7-Hydroxy Warfarin (S)-6-Hydroxy Warfarin Warfarin Impurity 1 2,6-Di-tert-butyl-4-mercaptophenol 7-HYDROXYWARFARIN (R)-8-HYDROXY WARFARIN 6-HYDROXYWARFARIN 8-HYDROXYWARFARIN 7-HYDROXYWARFARIN (S)-(-)-WARFARIN,(S)-WARFARIN