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| | N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Basic information |
| Product Name: | N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline | | Synonyms: | 4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE;4-(4-Benzyloxybenzylidene)Fluoroaniline;N-(4-(benzyloxy)benzylidene)-4-fluorobenzenamine;4-Fluoro-N-[[4-(phenylmethoxy)phenyl]methylene]benzenamine;N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline;4, 4-Benzyloxybenzylidene P- Fluoroaniline;4-Benzyloxybenzylidene-(4-f...;BenzenaMine,4-fluoro-N-[[4-(phenylMethoxy)phenyl]Methylene]- | | CAS: | 70627-52-0 | | MF: | C20H16FNO | | MW: | 305.35 | | EINECS: | 615-134-0 | | Product Categories: | | | Mol File: | 70627-52-0.mol |  |
| | N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Chemical Properties |
| Melting point | 136-138 ºC | | Boiling point | 455.2±35.0 °C(Predicted) | | density | 1.07 | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Acetonitrile (Slightly), Chlorofrom (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 3.71±0.50(Predicted) | | color | Very Dark Orange | | InChI | InChI=1S/C20H16FNO/c21-18-8-10-19(11-9-18)22-14-16-6-12-20(13-7-16)23-15-17-4-2-1-3-5-17/h1-14H,15H2 | | InChIKey | IWNBEFDVKWCBFY-UHFFFAOYSA-N | | SMILES | C1(N=CC2=CC=C(OCC3=CC=CC=C3)C=C2)=CC=C(F)C=C1 | | CAS DataBase Reference | 70627-52-0 |
| | N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Usage And Synthesis |
| Uses | 4-Benzyloxybenzylidene 4-Fluoroaniline is an intermediate in the synthesis of Linezolid (L466500). | | Synthesis | General procedure for the synthesis of 4-benzylbenzylidene-(4-fluoro)aniline from 4-benzyloxybenzaldehyde and 4-fluorobenzenamine: 4-fluorobenzylidene-(4-fluoro)aniline (100 g, 1.1 eq.) was mixed with isopropanol (1730 ml, 10 V) and heated under mechanical stirring up to 40 °C, whereby a large amount of light yellow crystalline solid was gradually precipitated. Stirring was continued and the reaction was monitored until completion. The heating was stopped and the reaction was cooled naturally to room temperature with stirring. Extraction and filtration operations were carried out, and the filter cake was washed with cold isopropanol and dried to give the light yellow crystalline product SM 2 with a mass of 238 g, 95% yield and 99% purity. | | References | [1] Patent: JP2016/147843, 2016, A. Location in patent: Paragraph 0016
[2] Patent: CN107793339, 2018, A. Location in patent: Paragraph 0021; 0023; 0031; 0038
[3] Pharmacy and Pharmacology Communications, 2000, vol. 6, # 1, p. 25 - 29
[4] Journal of Organic Chemistry, 2018, |
| | N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Preparation Products And Raw materials |
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