| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-HER2 antibody produced in mouse
Purity:Prestige Antibodies(R) Powered by Atlas Antibodies, clone CL Package:100UL Remarks:AMAB90628-100UL
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:purified immunoglobulin, 1 mg/mL Remarks:Prestige Antibodies? Powered by Atlas Antibodies, clone CL0268, purified immunoglobulin, buffered aqueous glycerol solution
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| Company Name: |
Alexis Corporation
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| Tel: |
+41 61 926 8989 |
| Email: |
alexis-ch@alexis-corp.ch |
| Products Intro: |
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| | ANTI-C-ERBB-2 Basic information |
| Product Name: | ANTI-C-ERBB-2 | | Synonyms: | ANTI-C-ERB-2;ANTI-C-ERB-2 (HUMAN);ANTI-C-ERBB-2;ANTI-HER-2/HUMAN;ANTI-HER-2, NEU;ANTI-HER-2/NEU (HUMAN);ANTI-HER-2;ANTI-ERBB2 (HUMAN) | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-C-ERBB-2 Structure]() |
| | ANTI-C-ERBB-2 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-C-ERBB-2 Usage And Synthesis |
| Uses | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper) | | General Description | Human epidermal growth factor receptor 2 (HER2), also known as Erb-b2 receptor tyrosine kinase 2 (ErbB2), is encoded by the gene mapped to human chromosome 17. The encoded protein is a member of epidermal growth factor family. HER2 membrane protein is characterized with a cysteine-rich extracellular ligand-binding domain, a hydrophobic membrane spanning region and an intracellular tyrosine kinase domain.This protein does not have a ligand., It either forms heterodimers with other family members or homodimer with itself, when expressed at very high levels, to get activated. HER2 is expressed at low level in normal tissues, but at high level in breast cancer tissues. | | Biochem/physiol Actions | Receptor tyrosine-protein kinase erbB-2 is a protein tyrosine kinase that is encoded by the gene ERBB2. It belongs to the epidermal growth factor (EGF) receptor family. The protein lacks a ligand binding domain and requires co-receptors for ligand binding. It functions as a transcriptional regulator by binding to cyclooxygenase enzyme COX-2 gene promoter. Overexpression of this gene has been observed in several types of cancer including breast and ovarian cancers. ErbB-2 enhances the EGF and NDF induced tyrosine phosphorylation of other ErbB family of receptor tyrosine kinases. |
| | ANTI-C-ERBB-2 Preparation Products And Raw materials |
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