| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Serum amyloid P component
Purity:buffered aqueous solution Package:250μg, 250μg, 1mg Remarks:S5269
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| Company Name: |
Creative Peptides
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| Tel: |
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| Email: |
info@creative-peptides.com |
| Products Intro: |
Product Name:SAP
Purity:>98% Package:1g; 10g;100g;1kg Remarks:The sweet arrow peptide (SAP) is derived from the proline-rich N-terminal repetitive domain of gamma-zein, a storage protein of maize which has been shown to interact with membranes.
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| Company Name: |
Shanghai Toyang Biotechnology Co., LTD
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| Tel: |
021-59555769 13524932310 |
| Email: |
1405894150@qq.com |
| Products Intro: |
Product Name:Serum Amyloid P-Component；FTLCFR
Purity:>95% Package:5mg，10mg，50mg，100mg，500mg，1g
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:buffered aqueous solution Remarks:~1 mg/mL, affinity isolated antibody, buffered aqueous solution
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| | SERUM AMYLOID P COMPONENT, HUMAN Basic information |
| Product Name: | SERUM AMYLOID P COMPONENT, HUMAN | | Synonyms: | SERUM AMYLOID P COMPONENT;SERUM AMYLOID P COMPONENT, HUMAN;SERUM AMYLOID P COMPONENT, HUMAN SERUM;SERUM AMYLOID P COMPONENT, MOUSE;SERUM AMYLOID P COMPONENT, NORMAL MOUSE;SERUM AMYLOID P COMPONENT, NORMAL MOUSE STANDARD;SAP;SAP COMPONENT, HUMAN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![SERUM AMYLOID P COMPONENT, HUMAN Structure]() |
| | SERUM AMYLOID P COMPONENT, HUMAN Chemical Properties |
| storage temp. | 2-8°C | | form | buffered aqueous solution |
| | SERUM AMYLOID P COMPONENT, HUMAN Usage And Synthesis |
| Uses | Human serum amyloid P component has been used as a standard in a study to characterize it as a plasma marker for Parkinson′s disease by a proteomic approach. | | Biochem/physiol Actions | Serum amyloid P component (SAP) is named for its universal presence in amyloid deposits (senile plaque and neurofibrillary tangles) in Alzheimer patients although it is exclusively synthesized in the periphery. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. However, SAP appeared not to be required for A beta deposition since no endogenous SAP immunoreactivity was detectable in transgenic mouse overexpressing beta-protein precursor. SAP belongs to the pentraxins family of oligomeric serum proteins which is highly conserved through evolution. Its presence has been found in Limulus polyphemus haemolymph. A recent report demonstrated that, in the presence of calcium, SAP can bind to free DNA and chromatin released through apoptosis or necrosis, displacing histone H1 and causing its solubilization and degradation. SAP knock out mice developed antinuclear autoimmunity and glomerulonephritis. However, the protective role of SAP in human SLE is still controversial. In addition, SAP neutralizes LPS and is potentially useful in defense against serious gram-negative sepsis in humans. |
| | SERUM AMYLOID P COMPONENT, HUMAN Preparation Products And Raw materials |
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