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(+)-Camptothecin

(+)-Camptothecin Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: 86-18523575427
Email: sales@conier.com
Products Intro: Product Name:(+)-camptothecin
Purity:0.99 Package:1kg
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718
Email: sales@capotchem.com
Products Intro: Product Name:(+)-Camptothecin
CAS:7689-03-4
Purity:98% (Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:(+)-Camptothecin
CAS:7689-03-4
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Email: Candy@bj-chem.com
Products Intro: Product Name:(+)-Camptothecin
CAS:7689-03-4
Purity:99% Package:1kg;25kg;200kg Cardboard barrels Remarks:crystalline
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:7689-03-4
Purity:99% Package:500G;1KG;5KG;25KG

Lastest Price from (+)-Camptothecin manufacturers

  • Camptothecin
  • US $0.00 / KG
  • 2020-12-04
  • CAS:7689-03-4
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • (+)-Camptothecin
  • US $1.00 / g
  • 2020-11-20
  • CAS:7689-03-4
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 1000kgs
  • Camptothecin 7689-03-4
  • US $12.50 / mg
  • 2020-08-17
  • CAS:7689-03-4
  • Min. Order: 20mg
  • Purity: ≥98%
  • Supply Ability: 1000.00 kgs
(+)-Camptothecin Chemical Properties
Melting point 260 °C (dec.)(lit.)
alpha D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point 482.73°C (rough estimate)
density 1.3112 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. 2-8°C
solubility chloroform/methanol (4:1): 4 mg/mL
pkapKa 10.83 (Uncertain)
form solid
color yellow
Water Solubility insoluble
Merck 14,1735
BRN 631069
InChIKeyVSJKWCGYPAHWDS-FQEVSTJZSA-N
CAS DataBase Reference7689-03-4(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi,Xn
Risk Statements 36/37/38-25-20/21/22
Safety Statements 45-36/37/39-26-36
RIDADR UN 1544 6.1/PG 3
WGK Germany 3
RTECS UQ0492000
Hazard Note Irritant
HazardClass 6.1
PackingGroup 
HS Code 29399990
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
(+)-Camptothecin Usage And Synthesis
Chemical Propertieslight yellow crystal powde
UsesAntitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent
Usesantineoplastic
UsesAntitumor agent;Topoisomerase I inhibitor
Uses10-hydroxycamptothecine precursor, topoisomerase inhibitor, binds irreversibly to DNA-topoisomerase I complex
DefinitionChEBI: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Biological ActivityCytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor.
Anticancer ResearchCamptothecin (CPT) is a monoterpene indole alkaloid which is isolatedfrom the Chinese plant, Camptotheca acuminata (Nyssaceae) (Wall et al. 1966).CPT is used in cancer treatment since it is a potent inhibitor of DNA topoisomeraseI, which leads to DNA damage and the apoptosis in cancer cells. Studies have shownthat CPT itself is not suitable for clinical application since it has low water solubilityand certain side effects; therefore, water-soluble CPT derivatives such as topotecan and irinotecan were synthesized and have been successfully used for thetreatment of ovarian, lung, and colorectal cancers, and CPT has been approved by theFood and Drug Administration (FDA) of the USA. Currently, topotecan and irinotecanare all synthesized from natural camptothecin which is mainly extracted fromCamptotheca acuminata (Beegum et al. 2007). Subsequently, CPT was also recognizedand extracted from other plant species such as Ervatamia heyneana (Gunasekeraet al. 1979), Melliodendron megacarpum (Arisawa et al. 1981), Nothapodytes foetida(Govindachari and Viswanathan 1972), and Ophiorrhiza species (Beegum et al.2007). However, the extraction of CPT from plants is limited because of low yields(about 1 mg/g dry weight) and scanty natural resources (Lopez-Meyer et al. 1994),and scientists have used biotechnological ways especially cell culture methods forthe production of CPT and its derivatives (Kai et al. 2015).
Anticancer ResearchCPT is extracted from Camptotheca acuminata, also called Chinese ornamentaltree. Irinotecan and topotecan are semisynthetic derivatives of camptothecin, whichcan be used for the therapy of colorectal and ovarian and small cell lung carcinoma,respectively (Shoeb 2006). Camptothecin is a potent antitumor agent that targetstopoisomerase I (Desai et al. 2008). The synthetic derivatives of camptothecin[20-(S)-9-nitrocamptothecin and 20-(S)-camptothecin] have the antitumor effects inbreast, prostate, and melanoma cancers. CPT-11 is a new derivative that showsantitumor effects against metastatic colorectal cancer (Hosseini and Ghorbani2015). It selectively inhibits topoisomerase I which is involved in cleavage andreassembly of DNA (Balunas and Kinghorn 2005). Camptothecin inhibits thesynthesis of nucleic acid in L-120 cells and HeLa cells (Desai et al. 2008).
Anticancer ResearchIt has low watersolubility and sideeffects. Thus, usedfor clinical purposes.The chemicalmodification of itsderivatives (e.g.,topotecan andirinotecan) iscurrently used inchemotherapy.
(+)-Camptothecin Preparation Products And Raw materials
Preparation ProductsIrinotecan
Tag:(+)-Camptothecin(7689-03-4) Related Product Information
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