(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491)

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(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) manufacturers

  • RO0270608
  • RO0270608 pictures
  • $117.00
  • 2026-07-27
  • CAS:220846-33-3
  • Purity: 99.79%
  • Supply Ability: 10g
(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) Basic information
Product Name:(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491)
Synonyms:(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491);(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid;L-Phenylalanine, N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlorobenzoyl)amino]-
CAS:220846-33-3
MF:C24H19Cl3N2O4
MW:505.77766
EINECS:
Product Categories:
Mol File:220846-33-3.mol
(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) Structure
(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) Chemical Properties
Boiling point 633.0±55.0 °C(Predicted)
density 1.447±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka3.60±0.10(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) Usage And Synthesis
UsesRO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. Antiinflammatory activity[1][2].
in vivo

In a murine OVA-model of airway inflammation, RO0270608 i.n. abolishes allergen-induced inflammatory cell accumulation[2]

IC 50α4β1; α4β7
References[1] Hijazi Y, et al. Pharmacokinetics, safety, and tolerability of R411, a dual alpha4beta1-alpha4beta7 integrin antagonist after oral administration at single and multiple once-daily ascending doses in healthy volunteers. J Clin Pharmacol. 2004;44(12):1368-1 DOI:10.1177/0091270004270147
[2] M. Renzetti, et al. Dual α4/β1–α4/β7 vs α4/β1 selective antagonism is required for attenuation of allergic inflammatory responses. Journal of Allergy and Clinical Immunology. Volume 113, Issue 2, Supplement, February 2004, Page S221.
(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491) Preparation Products And Raw materials
Tag:(S)-2-(2-chloro-6-methylbenzamido)-3-(4-(2,6-dichlorobenzamido)phenyl)propanoic acid(WXG00491)(220846-33-3) Related Product Information
Integrin alpha V beta 8 protein, human (HEK293, His-AVI) Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer Arg-Gly-Asp Integrin alpha V beta 6 protein, human (HEK293, FLAG-His) Integrin alpha V beta 8 protein, human (biotinylated, HEK293, His-AVI) Cyclo (Arg-Gly-Asp-D-Phe-Lys)