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Naphazoline

Naphazoline Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:naphazoline
CAS:835-31-4
Purity:0.99 Package:1kg
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Tel: +86-0371-86658258
Email: factory@coreychem.com
Products Intro: Product Name:Naphazoline
CAS:835-31-4
Purity:97%-99.9% Package:1KG;1USD
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
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Products Intro: Product Name:naphazoline
CAS:835-31-4
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
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Products Intro: Product Name:Naphazoline
CAS:835-31-4
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
Company Name: AFINE CHEMICALS LIMITED
Tel: 0571-85134551
Email: info@afinechem.com
Products Intro: Product Name:NAPHAZOLINE
CAS:835-31-4
Purity:98%+ Package:Standard or custom package Remarks:excellent quality and reliable supplier

Naphazoline manufacturers

  • Naphazoline
  • $0.00 / 1kg
  • 2022-06-02
  • CAS:835-31-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg
  • naphazoline
  • $50.00 / 1KG
  • 2021-08-31
  • CAS:835-31-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500tons/month
  • Naphazoline USP/EP/BP
  • $1.10 / 1g
  • 2021-07-28
  • CAS:835-31-4
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
Naphazoline Basic information
Product Name:Naphazoline
Synonyms:4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE;2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE;1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-;NAFAZOLINE;2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;Naphazoline;2-(1-Naphtylmethyl)-2-imidazoline;2-(1-Naphtylmethyl)-4,5-dihydro-1H-imidazole
CAS:835-31-4
MF:C14H14N2
MW:210.27
EINECS:212-641-5
Product Categories:API
Mol File:835-31-4.mol
Naphazoline Structure
Naphazoline Chemical Properties
Melting point 254 °C
Boiling point 339.81°C (rough estimate)
density 1.1063 (rough estimate)
refractive index 1.6180 (estimate)
storage temp. 2-8°C
pkapKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
CAS DataBase Reference835-31-4(CAS DataBase Reference)
NIST Chemistry ReferenceNaphazoline(835-31-4)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS NJ4375000
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Naphazoline Usage And Synthesis
OriginatorPrivine,Ciba,US,1942
UsesAdrenergic (vasoconstrictor).
UsesNaphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.
Manufacturing Process2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.
Brand nameAlbalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).
Therapeutic FunctionNasal decongestant
SynthesisNaphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Synthesis_835-31-4

Tag:Naphazoline(835-31-4) Related Product Information
NAPHAZOLINE NITRATE - REFERENCE SPECTRUM NAPHAZOLINE NITRATE IMP. C (EP): (1-NAPHTHYL)ACETONITRILE MM(CRM STANDARD) NAPHAZOLINE IMPURITY A NAPHAZOLINE HYDROCHLORIDE EPN(CRM STANDARD) NAPHAZOLINE NITRATE IMP. A (EP): (1-NAPHTHYL)ACETYLETHYLENDIAMINE NAPHAZOLINE NITRATE IMP. A (EP): (1-NAPHTHYL)ACETYLETHYLENDIAMINE MM(CRM STANDARD) NAPHAZOLINE HYDROCHLORIDE NASAL DROPS NAPHAZOLINE (BASE) Naphazoline HCL USP23 NAPHAZOLINE NITRATE REFERENCE SPECTRUM EPY(CRM STANDARD) NAPHAZOLINE HCL USP(CRM STANDARD) NAPHAZOLINE NITRATE IMP. B (EP): (NAPHTHALEN-1-YL)ACETIC ACID(1-NAPHTHYLACETIC ACID) NAPHAZOLINE NITRATE IMP. C (EP): (NAPHTHALEN-1-YL)ACETONITRILE(1-NAPHTHYLACETONITRILE) Naphazoline nitrate bp98 NAPHAZOLINE HYDROCHLORIDE - REFERENCE SPECTRUM NAPHAZOLINE HYDROCHLORIDE IMP. C (EP): (1-NAPHTHYL)ACETONITRILE MM(CRM STANDARD) NAPHAZOLINE HCL,NAPHAZOLINE HYDROCHLORIDE,NAPHAZOLINE HYDROCHLORIDE EXTRA PURE PH EUR,BP,USP,Naphazoline·hydrochloric acid Naphazoline