- SPINOSAD
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- $10.00 / 1KG
-
2025-11-14
- CAS:131929-60-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Spinosad
-
- $0.00 / 1KG
-
2025-11-14
- CAS:131929-60-7
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 100kg
- SPINOSAD
-
- $5.00/ KG
-
2025-11-03
- CAS:131929-60-7
- Min. Order: 1KG
- Purity: 99% hplc
- Supply Ability: 500TONS
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| | SPINOSAD Basic information |
| Product Name: | SPINOSAD | | Synonyms: | SPINOSAD;(2r-(2r*,3as*,5ar*,5bs*,9s*,13s*(2r*,5s*,6r*),14r*,16as*,16br*))-ethyl;)oxy)-13-((5-dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-14-m;1H-As-indaceno(3,2-D)oxacyclododecin-7,15-dione, 2,3,3A,5A,5B,6,9,10,11,12,13,14,16A,16B-tetradecahydro-2-((6-deoxy-2,3,4-tri-o-methyl-alpha-L-mannopyranosyl)oxy)- 13-((5-dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-9-ethyl-14-methyl-, (2R-(2R*,3as*,5ar*,5bs*,9S*,13S*(2R*,5S*,6R*),14R*,16as*,16br*))-;Ccris 8937;Hsdb 7006;Lepicidin A, A 83543A, LY 232105;1h-as-indaceno(3,2-d)oxacyclododecin-7,15-dione,2,3,3a,5a,5b,6,9,10,11,12,13,1 | | CAS: | 131929-60-7 | | MF: | C41H65NO10 | | MW: | 731.96 | | EINECS: | 620-162-1 | | Product Categories: | | | Mol File: | 131929-60-7.mol |  |
| | SPINOSAD Chemical Properties |
| Boiling point | 801.5±65.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | vapor pressure | Spinosyn A: 3.2 x 10-8 Pa
Spinosyn D: 2.1 x 10-8 Pa | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | solid | | pka | Spinosyn A: 8.1 (base);
Spinosyn D: 7.8 (base) | | Water Solubility | Spinosyn A: 290 mg l-1 (pH 5);
Spinosyn D: 29 mg l-1 (pH 5) | | color | White to off-white | | InChIKey | SRJQTHAZUNRMPR-XOBNMGJWNA-N | | EPA Substance Registry System | Spinosyn A (131929-60-7) |
| | SPINOSAD Usage And Synthesis |
| Chemical Properties | Light gray-white solid crystal, with a slight stale earthy odor. Vapor pressure is about 1.3×10-10 Pa. In pH 7.74 aqueous solution, it is relatively stable to metals and metal ions within 28d. In the soil photodegradation half-life of 9 ~ 10d; water photolysis half-life <1d. In the pH value of 5 ~ 7 range, in aqueous solution is relatively stable; in the pH value of 9 when the half-life of >200d. Multi-bactericides is a mixture containing more than ten components, the main components are A and D. Spinosyn A melting point of 84 ~ 99.5 ° C, vapour pressure of 3.2 × 10-10Pa The solubility in water was 290mg/L (pH=5.0), 235mg/L (pH=7.0), 16mg/L (pH=9.0); the partition coefficients were 2.8, 4.0, 5.2 under the corresponding pH conditions, respectively.The melting point of polymicrobialin D was 161.5~170°C, and the vapour pressure was 2.1×10-10 Pa. The solubility in water was 29mg/L (pH=7.0), 4.0, 5.2, respectively. The solubility in water was 29mg/L (pH=5.0), 0.332mg/L (pH=7.0), 0.053mg/L (pH=90.0), and the partition coefficients were 3.2, 4.5, and 5.2 under the corresponding pH conditions. | | Uses | Spinosyn A is the major component of a complex of unusual, hydrophobic macrocyclic lactones isolated from Saccharopolyspora spinosa in 1991. The 12-membered macrocyclic lactone is fused to form a rare 12-5-6-5 tetracyclic ring system, with the macrocycle and the terminal cyclopentane bearing glycosides. Spinosyn A is a potent insecticide for crop pathogens and ectoparasite control on animals. The spinosyns have a unique mechanism of action involving disruption of nicotinic acetylcholine receptors. | | Definition | ChEBI: A spinosyn in which the sugar amino and hydroxy groups are globally methylated. One of the two active ingredients of spinosad. | | Biological Activity | spinosyn a is an insect nicotinic acetylcholinesterase receptors (nachrs) agonist and potent insecticide.the spinosyns are a family of macrolide natural products produced by the soil microorganism saccharopolyspora spinosa. spinosyn a is identified as a naturally-occurring macrocyclic lactone that is a potent insecticide. | | Veterinary Drugs and Treatments | For the prevention and treatment of fleas for one month on dogs 14 weeks of age and older.
Spinosad is a group 5 nicotinic acetylcholine receptor agonist, that causes involuntary muscle contractions and tremors secondary
to motor neuron activation. Prolonged exposure causes paralysis and flea death. Flea death begins within 30 minutes of dosing and in 4
hours is complete. Spinosad does not interact with bindings sites of other insecticidal agents (GABA-ergic or nicotinic). | | in vitro | the mixture of spinosyns a and d, a commercial insecticide tracertm (dowagrosciences), is useful against various crop pests such as tobacco budworm. it was found that the deoxy analogs of spinosyns a were more potent insecticides than their respective parent factor. moreover, the 2’-desmethoxy analogs of spinosyns a showed insecticidal potency against h. virescens greater than that of spinosyns a and d, suggesting that polarity was not well tolerated. furthermore, the activity of 3'-deoxy spinosyn j was about the same as spinosyn a, and the activity of 2'-deoxy spinosyn h was found to be slightly greater than that of spinosyn a [1]. | | Metabolic pathway | Spinosad consists of two major components, namely
psinosyns A (ca 85%) and D (ca 15%). When either
14C-spinosyn A or -spinosyn D is applied in the soil
under aerobic conditions, the major degradation
product of spinosyn A is spinosyn B, resulting from demethylation on the forosamine sugar. Other
degradation products are hydroxylation products of
psinosyns A and B, probably on the aglycone portion
of the molecule. | | Degradation | Spinosad is relatively stable in water with no observed decomposition
between pH 5 and 7. Measured DT50 values at pH 9 were 200 and 259
days, respectively, for spinosyns A and D (Saunders and Bret, 1997).
Aqueous photolysis was very rapid with a DT50 of < 1 day in pH 7 buffered
water at 25 °C (DowElanco, 1996). Spinosad was rapidly dissipated
and degraded in an outdoor mesocosm study and on plant surfaces
(Saunders and Bret, 1997). | | Toxicity evaluation | Acute oral LD50 for rats: 2,000-5,000 mg/kg | | references | [1] l. c. creemer, h. a. kirst, j. w. paschal, et al. synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety. j.antibiot.(tokyo) 53(2), 171-178 (2000). |
| | SPINOSAD Preparation Products And Raw materials |
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